A direct injection, liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed for the analysis of the chloro-s-triazine herbicides and their degradates in finished drinking water. The target compounds in the method were selected based on their inclusion in a common mechanism group (CMG) because of their ability to induce a similar toxic effect through a common mechanis...

PURPOSE Adenoviral keratoconjunctivitis is recognized as one of the major pathogens of ophthalmological nosocomial infection worldwide. N-Chlorotaurine (Cl-HN-CH(2)-CH(2)-SO(3)H, NCT) is the N-chloro derivative of the amino acid taurine, which is an oxidant produced by human granulocytes and monocytes during inflammatory reactions. Using conventional viral plaque assay, it was previously shown ...

The title compound, [Ti(C(15)H(23)N(2)Si)Cl(3)]·0.5C(4)H(8)O, has been prepared from {2-[2-(η(5)-cyclo-penta-dien-yl)-2-methyl-prop-yl]-1H-imidazolyl-κN(1)}bis-(N,N-diethyl-amido-κN)titanium(IV), (C(12)H(14)N(2))Ti(NEt(2))(2), by reaction with excess of Me(3)SiCl in tetra-hydro-furan (THF) at 353 K. The crystal structure contains THF as adduct solvent, disordered around a center of inversion. T...

SIR, We present a PM patient refractory to standard therapy, who showed effective clinical remission after a single treatment cycle with alemtuzumab for >3 years of follow-up. This is, to our knowledge, the first report of long-term efficacy of alemtuzumab in the treatment of PM. This Caucasian male patient was born in 1957. PM manifested at the age of 52 with progressive symmetrical muscle wea...

EDITOR: Although it is commonly used in clinical practice, there is not much awareness of the allergic potential of atropine since there are some reports of adverse reactions but rarely with clinical significance [1]. In the current literature on allergic reactions during anaesthesia, atropine appears in a very small number of patients, unlike the more frequent causative agents such as neuromus...

The chloro-S-triazine herbicides (i.e., atrazine, simazine, cyanazine) constitute the largest group of herbicides sold in the United States. Despite their extensive usage, relatively little is known about the possible human-health effects and mechanism(s) of action of these compounds. Previous studies in our laboratory have shown that the chlorotriazines disrupt the hormonal control of ovarian ...

Crystals of bis-(tetra-butyl-ammonium) di-μ3-chlorido--tris-(μ2-4-iodo-pyrazolato-κ2N:N')tris-[chlorido-cuprate(II)] 1,4-dioxane hemisolvate, (C16H36N)2[Cu3(C3H2IN2)3Cl5]·0.5C4H8O or (Bu4N)2[CuII3(μ3-Cl)2(μ-4-I-pz)3Cl3]·0.5C4H8O, were obtained by evaporating a solution of (Bu4N)2[{CuII(μ-OH)(μ-4-I-pz)} n CO3] (n = 27-31) nanojars in chloro-form/1,4-dioxane. The decomposition of chloro-form in t...

We investigated a potential mechanism for the estrogenic properties of three chloro-s-triazine herbicides and six metabolites in vitro in several cell systems. We determined effects on human aromatase (CYP19), the enzyme that converts androgens to estrogens, in H295R (adrenocortical carcinoma), JEG-3 (placental choriocarcinoma), and MCF-7 (breast cancer) cells; we determined effects on estrogen...

Granuloma faciale (GF) is a rare skin disorder with a chronic-relapsing course. Cutaneous lesions affect predominantly the face of middle-aged Caucasian men with characteristic reddish papules, nodules, or plaques; however, various atypical cases with unusual morphology or extra facial involvement have been reported (1-3). Despite many treatment options, both surgical and medical, GF remains th...

Pharmacological compounds enhancing serotonergic tone significantly decrease food intake and are among the most clinically efficacious treatments for obesity. However, the central mechanisms through which serotonergic compounds modulate feeding behavior have not been fully defined. The primary relay center receiving visceral gastrointestinal information in the central nervous system is the nucl...