Background: Diffuse hair loss is one of the most common complaints of women attending skin clinics. Objective: The purpose of this study was to evaluate diffuse hair loss in women referring to a private office. Patients and Methods: This descriptive, retrospective study was performed on women attending a private skin clinic in Ahwaz complaining of diffuse hair loss. The study was done for 10 mo...

this is a case of a patient with bowel obstruction , imaging studies were suggestive for pneumatosis intestinalis. clinically diagnosed as adhesion band and pnematosis intestinalis. she underwent laparatomy, enterolysis, obstructionolysis and enterorrhaphy. the patient developed respiratory distress and expired after 2 days. at autopsy we found gray-brown discoloration in the wall of some part ...

neuroblastoma is a common tumor in pediatric cancer and which might present with usual or unusual clinical features. one of the rare clinical finding of neuroblastoma is paraneoplastic syndromes. we report a two year-old girl with presentation of bilateral ptosis and abdominal pain which was diagnosed as having neuroblastoma. our case is a very rare case of neuroblastoma accompanied by bilatera...

Early phase dose-finding (EPDF) trials are crucial for the development of a new intervention and influence whether it can be investigated in further trials. Guidance exists clinical trial protocols reports SPIRIT CONSORT guidelines, respectively. The features EPDF not well addressed both guidelines their extensions. Building on checklists, DEFINE study aims to develop international consensus-dr...

Neuroblastoma is a common tumor in pediatric cancer and which might present with usual or unusual clinical features. One of the rare clinical finding of neuroblastoma is paraneoplastic syndromes. We report a two year-old girl with presentation of bilateral ptosis and abdominal pain which was diagnosed as having neuroblastoma. Our case is a very rare case of neuroblastoma accompanied by bilat...

Pseudoporphyria is an uncommon bullous disease with similar clinical and histopathological findings to porphyria cutanea tarda, in the absence of detectable porphyrin elevation. We present a 34-year-old man with clinical and histological findings compatible with porphyria cutanea tarda, whose his urinary uroporphyrin was negative and we concluded that he was a case of pseudoporphyria. Concomita...

INTRODUCTION Clostridium difficile infections predominatelly occur among hospitalized patients. The aim of this study was to evaluate the importance of finding the isolate of Clostridium difficile cultured from the stool of hospitalized patients. MATERIAL AND METHODS Material consisted of 100 patients with at least one liquid stool samples and control group with form stool. Every patient spen...

The breakout session 2 of the European Medicines Agency/European Federation of Pharmaceutical Industries and Associations Modeling and Simulation (M&S) workshop focused on two topics: when and how M&S should be used and would be accepted by the authorities for the dose-regimen selection; and when and how M&S can be applied to register a dosing regimen without the need for a specific study. Each...