Prediction models that use gene expression levels are now being proposed for personalized treatment of cancer, but building accurate models that are easy to interpret remains a challenge. In this paper, we describe an integrative clinical-genomic approach that combines both genomic pathway and clinical information. First, we summarize information from genes in each pathway using Supervised Prin...

background: stroke is a leading cause of death all around the world, and ischemic stroke is considered to be the most common stroke type. toll-like receptors (tlrs) are important molecules for detection of both pathogen invasion and tissue damage. in this regard, the purpose of this study was to assess the expression level of tlr2 on monocytes in patients with ischemic stroke and to evaluate th...

among the lesions induced by chemotherapeutic drugs, dna double-strand breaks (dsb) are considered the most serious ones that can result in cell death, if it is not properly repaired. homologous recombination (hr) pathway is the main system for dsb repair and xrcc3 has a key role in this pathway. protein activity can be affected by the xrcc3 polymorphism. thus, in this study, the association be...

This paper proposes the Clinical Pathway Analysis Method (CPAM) approach that enables the extraction of valuable organisational and medical information on past clinical pathway executions from the event logs of healthcare information systems. The method deals with the complexity of real-world clinical pathways by introducing a perspective-based segmentation of the date-stamped event log. CPAM e...

: Metastasis spreading confers a worse prognosis to the clinical outcome among patients suffering from osteosarcoma, most common primary bone tumor in childhood and adolescence. The detection of molecules involved metastasis might contribute understanding dissemination mechanisms, thereby opening way novel therapeutic strategies. Ezrin-radixin-moesin (ERM) family proteins are activated after in...

Long-term potentiation (LTP) is a biological process of learning and memory after a high-frequency train of electrical stimulations. By binding of brain-derived neurotrophic factor (BDNF) to Tropomyosin receptor kinase B (TrKB) receptors in postsynaptic neurons, tyrosine kinase Fyn is bound to these receptors and hereby plays a mediating role to binding and activation of N-methyl-D-aspartic aci...

background: emotional intelligence (ei) helps humans to perceive their own and others’ emotions. it helps to make better interpersonal communication that consequently leads to an increase in everyday performance and professional career. teaching, particularly teaching in the clinical environment, is among the professions that need a high level of ei due to its relevance to human interactions. m...

evidence based medicine is very important for success of modern medicine. it is the ongoing process of using the most reliable evidence from clinical studies, scientific understanding and medical practice to make the best possible medical choice for patients. evidence based medicine is how medicine advances and how we get improvements in life expectancy and quality of life. it not only identifi...