Asthma is a heterogeneous disorder with multiple clinical phenotypes. Phenotypes can be grouped into clinical or physiological, trigger-defined, and inflammatory phenotypes. Treatment based on inflammatory phenotyping improves clinical measures of asthma morbidity. Further study of individual asthma phenotypes will improve understanding of their immunologic and pathologic characteristics and im...

Vasculitis syndromes are relative rare conditions but can cause significant mortality and morbidity if not treated adequately. Recent advances in immunosuppressant therapy have radically changed the course of these diseases. However, the standard therapy is not always well tolerated by patients, and some cases are refractory to treatment. New therapeutic possibilities have emerged with the use ...

Introduction: Dentigerous cysts (DCs) are the most common developmental cysts of the jaws, mostly associated with impacted third molars and canines. Multiple or bilateral DCs are rare and typically occur in association with some syndromes including cleidocranial dysplasia and Gorlin-Goltz. The occurrence of multiple DCs is rare in the absence of these syndromes. Case Presentation: A 28-year-ol...

mediastinal neoplasms are uncommon tumors that can occur at any age but are most common through the fifth decades of life. a wide variety of systemic disorders are associated with 71% of thymomas. the symptoms of these as sociated disorders often lead to the original discovery of the mediastinal tumor. a 35-year-old female with petechia and purpura was admitted to sina hospital of the city of h...

alcohol provokes different molecular pathways contributing to a clinically significant neurotoxicity in different brain areas. affected cognition in alcoholics can influence both daily life functioning and alcohol craving management abilities. preventing alcohol-induced neurotoxicity with different neuroprotective pharmacological interventions is receiving strong scientific backgrounds from pub...

acute coronary syndrome is the leading cause of mortality worldwide. for prompt diagnosis and management of this disease, several biomarkers have been utilized. recently microrna which are suggestive of tissue damage and some are cardiospecific are paid special attention and might help in dearly diagnosis of this disease and furthermore help in preventing the resultant mortality. in this review...

We define the diagnosis in Traditional Chinese Medicine (TCM) as discovering the fuzzy relations between symptoms and syndromes. An Ontology-oriented Diagnosis System (ODS) is created to address the knowledgebased diagnosis based on a well-defined ontology of syndromes. The ontology transforms the implicit relationships among syndromes into a machine-interpretable model. The clinical data used ...

The myelodysplastic syndromes (MDS) provide a clinical model for evaluating the evolution of a relatively indolent malignancy into one which is frankly aggressive. The morbidity and mortality in this myeloid clonal hemopathy relate to either marrow dysfunction associated with ineffective hematopoiesis and its peripheral blood cytopenias or to disease evolution into a variant of acute myeloid le...

B.C. McClain and S. Suresh (eds.), Handbook of Pediatric Chronic Pain: Current Science and Integrative Practice, DOI 10.1007/978-1-4419-0350-1_7, © Springer Science+Business Media, LLC 2011 The child presenting to the general practitioner with complaints of musculoskeletal pain is common and pediatricians need to be more knowledgeable of these conditions. It presents a challenge to make the dia...

J.S. BALAMI, R.L. CHEN and A.M. BUCHAN From the Acute Stroke Programme, Department of Medicine and Clinical Geratology, Oxford University Hospitals NHS Trust, Oxford, UK, Acute Stroke Programme, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK, Institute for Science and Technology in Medicine, School of Pharmacy, Keele University, Staffordshire, UK and Acute Vascular I...