GPSzero-difference applicationswith a sampling rate up to 1Hz require corresponding high-rate GPS clock corrections. The determination of the clock corrections in a full network solution is a time-consuming task. The Center for Orbit Determination in Europe (CODE) has developed an efficient algorithm based on epoch-differenced phase observations, which allows to generate high-rate clock correct...

This paper investigates the application of simultaneous retiming and clock scheduling for optimizing synchronous circuits under setup and hold constraints. Two optimization problems are explored: (1) clock period minimization and (2) tolerance maximization to clock-signal delay variations. Exact mixed-integer linear programming formulations and efficient heuristics are given for both problems. ...

Circadian rhythm abnormalities in bipolar disorder (BD) have led to a search for genetic abnormalities in circadian "clock genes" associated with BD. However, no significant clock gene findings have emerged from genome-wide association studies (GWAS). At least three factors could account for this discrepancy: complex traits are polygenic, the organization of the clock is more complex than previ...

Modern field-programmable gate array (FPGA) devices contain complex clock architectures on top of configurable logics. Unlike application specific integrated circuits (ASICs), the physical structure of clock networks in an FPGA is pre-manufactured and cannot be adjusted to different applications. Furthermore, clock routing resources are typically limited for high-utilization designs. Consequent...

Comparative studies on cellular and molecular clock mechanisms have revealed striking similarities in the organization of the clocks among different animal groups. To gain evolutionary insight into the properties of the clock network within the Drosophila genus, we analyzed sequence identities and similarities of clock protein homologues and immunostained brains of 10 different Drosophila speci...

Daily rhythms such as sleep-wake, feeding, and the core body temperature, persist with a period of approximately 24 hr even in the absence of environmental time cues, suggesting the existence of an endogenous time-keeping system , the circadian clock. In mammals, the circadian clock is located in the suprachiasmatic nucleus of the hypothalamus (SCN). Recently, a number of studies have revealed ...

In the Drosophila circadian clock, the CLOCK/CYCLE complex activates the period and timeless genes that negatively feedback on CLOCK/CYCLE activity. The 24-h pace of this cycle depends on the stability of the clock proteins. RING-domain E3 ubiquitin ligases have been shown to destabilize PERIOD or TIMELESS. Here we identify a clock function for the circadian trip (ctrip) gene, which encodes a H...

This paper overviews clock design problems related to the circuit reliability in deep submicron design technology. The topics include the clock polarity assignment problem for reducing peak power/ground noise, clock mesh network design problem for tolerating clock delay variation, electromagnetic interference aware clock optimization problem, adjustable delay buffer allocation and assignment pr...

In highly reliable and durable systems, failures due to aging might result in catastrophes. Aging monitoring techniques to prevent catastrophes by predicting such a failure are required. Aging can be monitored by performing a delay test at faster clocks than functional clock in field and checking the current delay state from the test clock frequencies at which the delay test is passed or failed...

By regulating the metabolism of fatty acids, carbohydrates, and xenobiotic, the mammalian circadian clock plays a fundamental role on the liver physiology. At present, it is supposed that the circadian clock regulates metabolism mostly by regulating the expression of liver enzymes at the transcriptional level. However, recent evidences suggest that some signaling pathways synchronized by the ci...