Antigen uptake, processing and presentation by antigen presenting cells (APCs) are tightly coupled processes which consequently lead to the activation of innate and adaptive immune responses. However, the regulatory role of microRNA (miRNAs) in these critical pathways is poorly understood. In this study, we show that overexpression of miR-24, miR-30b and miR-142-3p attenuates uptake and process...

Mercury emissions from coal fired power plants are generally measured using one of two methods electronic Continuous Emission Monitoring Systems (Hg CEMS) that most commonly use atomic fluorescence, or sorbent traps. Electronic Hg CEMS are often compared against sorbent traps using EPA’s Method 30B Relative Accuracy Test Audit (RATA). Because sorbent traps include mercury contained in the parti...

We have systematically investigated the phase diagram of clay particles in water to understand the relation between the local and macroscopic properties and the structures of clay suspensions. We focused, in particular, on sodium Cloisite (CNa) particles at concentrations typically used in nanocomposites (concentrations from 1 to 4 wt %) and at an extended range of ionic strengths (10(-5) to 10...

We address the problem of scalable distributed reasoning, proposing a technique for materialising the closure of an RDF graph based on MapReduce. We have implemented our approach on top of Hadoop and deployed it on a compute cluster of up to 64 commodity machines. We show that a naive implementation on top of MapReduce is straightforward but performs badly and we present several non-trivial opt...

A panel of murine hepatitis virus (MHV) surface (S) glycoprotein-specific monoclonal antibodies (MAbs), which recognize either continuous or discontinuous epitopes, were tested in competitive binding assays. The results indicate that the binding site of MAb 30B amino acids 395 to 406 in the amino-terminal S1 subunit, is involved in the discontinuous epitope designated antigenic site A. This sit...

425 Background: Existing conventional serum tumor markers (STMs) exhibit moderate performance for the detection of germ cell tumors (GCTs). Circulating miR-371a-3p has excellent in viable (non-teratoma) GCT pre-orchiectomy; however, its ability to detect occult disease is understudied. We refine assay and expand upon our previous experience this setting. Methods: compared raw (Cq) normalized (∆...