ORIGINAL ARTICLES Reduced semen quality and risk behaviour amongst men consulting a referral STD clinic.... Lymphoproliferative malignancies in association with endemic African Kaposi’s Sarcoma............ Determination of appropriate clomipramine dosage among depressed African outpatients in Dar es Salaam, Tanzania...................................... Bronchoscopic extraction of aspirated for...

ORIGINAL ARTICLES Reduced semen quality and risk behaviour amongst men consulting a referral STD clinic.... Lymphoproliferative malignancies in association with endemic African Kaposi’s Sarcoma............ Determination of appropriate clomipramine dosage among depressed African outpatients in Dar es Salaam, Tanzania...................................... Bronchoscopic extraction of aspirated for...

Polymorphisms in CYP2D6 and CYP2C19 affect the efficacy and safety of tricyclics, with some drugs being affected by CYP2D6 only, and others by both polymorphic enzymes. Amitriptyline, clomipramine, doxepin, imipramine, and trimipramine are demethylated by CYP2C19 to pharmacologically active metabolites. These drugs and their metabolites, along with desipramine and nortriptyline, undergo hydroxy...

ORIGINAL ARTICLES Reduced semen quality and risk behaviour amongst men consulting a referral STD clinic.... Lymphoproliferative malignancies in association with endemic African Kaposi’s Sarcoma............ Determination of appropriate clomipramine dosage among depressed African outpatients in Dar es Salaam, Tanzania...................................... Bronchoscopic extraction of aspirated for...

Exercise exerts antidepressant effects in humans and rodent models of affective disorders. These effects may be mediated by the upregulation of endogenous factors that exert antidepressant actions. The physiological functions and behavioral actions of the neuropeptide galanin (GAL) suggest antidepressant activity. Previous studies have shown that various modes of exercise elevate GAL gene expre...

BACKGROUND AND PURPOSE Rat major cerebral arteries seem to receive serotonergic fibers originating from the dorsal raphe nucleus (DRN), but little is known about their function. The aim of our present work was to establish a functional relationship between this brain stem nucleus and the cerebral blood vessels by studying the effects of several treatments in the DRN on cerebrovascular serotoner...