نتایج جستجو برای: clonal
تعداد نتایج: 24991 فیلتر نتایج به سال:
The preponderant clonal evolution hypothesis (PCE) predicts that frequent clonal reproduction (sex between two clones) in many pathogens capable of sexual recombination results in strong linkage disequilibrium and the presence of discrete genetic subdivisions characterized by occasional gene flow. We expand on the PCE and predict that higher rates of clonal reproduction will result in: (1) morp...
Phytophthora ramorum, the causal agent of sudden oak death and ramorum blight, is known to exist as three distinct clonal lineages which can only be distinguished by performing molecular marker-based analyses. However, in the recent literature there exists no consensus on naming of these lineages. Here we propose a system for naming clonal lineages of P. ramorum based on a consensus established...
Background: It is generally assumed that short-term population dynamics are too slow to be influenced by evolution. Question: Can evolution occurring within only weeks (four to five generations) impact concurrent population dynamics? Organism: Green peach aphid (Myzus persicae) growing on an undomesticated host (Hirschfeldia incana). Aphid clones were collected from a single wild population. Si...
The clonal age in paramecia refers to the total number of vegetative divisions a clone has undergone since its origin at autogamy (self-fertilization). As clonal age increases, the interfission time usually increases. The DNA synthesis pattern of cells of different ages was compared by autoradiographic analysis of the DNA synthesis of synchronized cells at various time intervals during the cell...
The Epstein-Barr virus (EBV) is associated with distinct forms of human lymphoid malignancies, including the endemic (eBL) and sporadic forms of Burkitt's lymphoma (sBL) and acquired immunodeficiency syndrome-associated non-Hodgkin lymphoma (AIDS-NHL). However, whether EBV has a pathogenetic role in these tumors or is a passenger virus has not been conclusively demonstrated. One element to dist...
A series of acquired immunity inspired clonal selection models have previously been proposed that includes principle model components and base (single repertoire) models. Also previously proposed is a contrived problem domain called ‘colour space’ and a number of scenarios intended for the investigation of adaptive models. This work units these two (until now) isolated streams of work by realiz...
This paper deals with a new model for clonal network dynamics. We describe in detail this model and derive special equations governing immune system dynamics based on the general gradient type principles that can be inherent to a wide class of real living objects. A special clonal network is modeled by two symmetric projector matrix variables simultaneously taking into account both asymmetry of...
Clonal hemopoiesis driven by leukemia-associated gene mutations can occur without evidence of a blood disorder. To investigate this phenomenon, we interrogated 15 mutation hot spots in blood DNA from 4,219 individuals using ultra-deep sequencing. Using only the hot spots studied, we identified clonal hemopoiesis in 0.8% of individuals under 60, rising to 19.5% of those ≥90 years, thus predictin...
Relatedness strongly influences social behaviors in a wide variety of species. For most species, the highest typical degree of relatedness is between full siblings with 50% shared genes. However, this is poorly understood in species with unusually high relatedness between individuals: clonal organisms. Although there has been some investigation into clonal invertebrates and yeast, nothing is kn...
mecium has an intrinsic length of clonal life span which corresponds to organismal life span in multicellular organisms (Sonneborn, 1954). For the final purpose of identifying the jumyo gene, the causal determinant of the clonal life span of Paramecium tetraurelia (Takagi et al., 1989), we examined differences in gene expression between wildtype stock 51 and its mutant d4-SL4 which has an extre...
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