Background: Food-born botulism is caused by ingestion of contaminated food with clostridium botulinum neurotoxin. Case: In food-born botulism, due to acetylcholine release blockade, neuromuscular signs and symptoms are common, but in this case report we present a food-born botulism with papiledema and venous sinus thrombosis. Conclusion: Papiledema and fever could not rule out the diagnosis...

Tryptic activation of prototoxin of Clostridium botulinum type E increased the lethal toxicity by 250-fold, but no compatible increase in the antitoxin-combining power resulted. The formol toxoid derived from prototoxin and that from trypsin-activated 12S toxin were the same in the antigenic specificity, but prototoxin toxoid stimulated formation of a larger amount of antitoxin in guinea pigs a...

Botulinum toxin for injection is a purified and diluted protein which isolated from the bacterium Clostridium botulinum . It one of most potent toxins known to humankind. C. an anaerobic Gram-positive, spore-forming present naturally in soil, plants, static water bodies, gastrointestinal tract mammals aquatic life. Different formulations are available. FDA approval these varies. This article re...

Fiock, Mary A. (Fort Detrick, Frederick, Md.), Allen Yarinsky, and James T. Duff. Studies on immunity to toxins of Clostridium botulinum. VII. Purification and detoxification of trypsin-activated type E toxin. J. Bacteriol. 82:66-71. 1961.-A procedure was described for production, purification, and conversion to toxoid of the Clostridium botulinum type E trypsin-treated toxin. A medium containi...

The genetic relatedness of Clostridium botulinum type E isolates associated with an outbreak of wildlife botulism was studied using random amplification of polymorphic DNA (RAPD). Specimens were collected from November 2000 to December 2008 during a large outbreak of botulism affecting birds and fish living in and around Lake Erie and Lake Ontario. In our present study, a total of 355 wildlife ...

food-borne botulism is one of the dangerous food poisonings in human in the world. the specimens of 115 patients (serum and stool) with clinical symptoms of botulism, who were inpatient and outpatient were collected at some medical centers in tehran and other areas of iran, between april 1984 to august 1994. in this survey, specimens of 73 patients showed the toxin and spore of c.botulinum. clo...

Clostridium botulinum produces the most poisonous natural toxin known and is a perennial concern to the food industry and to regulatory agencies due to the potential threat of food-borne botulism. To ensure the botulinal safety of foods, rigorous food challenge testing to validate food-processing conditions and food formulations has been routinely performed. Detection of the botulinum neurotoxi...

Cause Avian botulism is a paralytic, often fatal, disease of birds that results when they ingest toxin produced by the bacterium, Clostridium botulinum. Seven distinct types of toxin designated by the letters A to G have been identified (Table 38.1). Waterfowl die-offs due to botulism are usually caused by type C toxin; sporadic die-offs among fish-eating birds, such as common loons and gulls, ...

A PCR was developed and applied for the detection of Clostridium botulinum type C in 18 avian and environmental samples collected during an outbreak of avian botulism, and the results were compared with those obtained by conventional methodologies based on the mouse bioassay. PCR and mouse bioassay results compared well (100%) after the enrichment of samples, but PCR results directly indicated ...