The usage of amorphous solids in practical applications, such as in medication, is commonly limited by the poor long-term stability of this state, because unwanted crystalline transitions occur. In this study, three different polymeric coatings are investigated for their ability to stabilize amorphous films of the model drug clotrimazole and to protect against thermally induced transitions. For...

Achieving a desirable percutaneous absorption of drug molecule is a major concern in formulating dermal and transdermal products. The use of penetration enhancers could provide a successful mean for this purpose. The aim of this study was to develop Clotrimazole gel and to evaluate the effect of almond oil and tween 80 (in different concentrations), on the permeation of drug through rabbit skin...

Background and Purpose: Otomycosis is an acute, subacute or chronic fungal infection of the pinna, the external auditory meatus and the ear canal caused mainly by several species of saprophytic fungi. Lamisil (Terbinafine) is an allylamine antifungal agent, that is used both in the topical and oral administration for the treatment of dermatophytosis, cutaneous candidiasis, and the pityriasis ve...

In vitro comparison on dermatophytes showed, on a microgram-per-milliliter basis, that tolciclate was more active than clotrimazole and miconazole in inhibiting the growth of dermatophytes in Sabouraud agar with and without 10% horse serum.

A single blind study of 103 women with vaginal candidosis was undertaken to compare treatment with conventional topical clotrimazole and oral ketoconazole. Both treatment regimens were equally effective in terms of clinical symptoms, negative results on culture for Candida albicans, and relapse rates. As treatment for vaginal candidosis takes several days, patient compliance is important and th...

A novel triiodide ion-selective electrode based on a clotrimazole-triiodide ion pair as a membrane carrier was prepared. It has a linear response to triiodide from 8 x 10(-6) to 5 x 10(-3) M with a slope of -68.9 mV per decade and a detection limit of 5 x 10(-6) M. The electrode response is independent of the pH of the solution in the pH range 2-9. It has a very short response time and can be u...

This study was conducted to examine the activity of alpha-mangostin against Candida albicans, the most important microorganism implicated in oral candidiasis. Its activity was compared to Clotrimazole and Nystatin. Results showed that alpha-mangostin was effective against C. albicans, the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 1,000 and 2,000 micr...

In the title cocrystal, C(10)H(8)O(2)·C(3)H(4)N(2), inter-molecular O-H⋯O and N-H⋯O hydrogen bonds connect the naphthalene-2,3-diol and imidazole mol-ecules into a two-dimensional supra-molecular framework.