Sporadic colorectal cancer (CRC) characterized by high-level DNA microsatellite instability (MSI-H) has a favorable prognosis. The reason for this MSI-H survival advantage is not known. The aim of this study was to correlate proliferation, apoptosis, and prognosis in CRC stratified by MSI status. The proliferative index (PI) was measured by immunohistochemical staining with the Ki-67 antibody i...

Research team: David A. Randall (Co-PI) Professor, Atmospheric Science Department, Colorado State University Dacian N. Daescu (Co-PI) Assistant Professor, Department of Mathematics and Statistics, Portland State University Steven J. Fletcher Cooperative Institute for Research in the Atmosphere, Colorado State University Bahri Uzuznoglu Department of Scientific Computing, Florida State Universit...

Objective: To determine the sensitivity and specificity of the pulsatile index in umbilical artery (PI-UA) and pulsatile index in middle cerebral artery (PI-MCA) in detecting IUGR by comparing it with the birth weight. Study Design: Validation study. Place and Duration of Study: Study was conducted in Department of Radiology, Military Hospital and Combined Military Hospital Rawalpindi, which wa...

Results: The mean values of peak systolic velocity, pulsatility index (PI) and resistive index (RI) of capsular artery (CA) and intratesticular artery (ITA) decreased significantly after LV and MV, whereas no significant change was observed in end-diastolic velocity. Comparing between two groups, the PI and RI values of left CA and ITA on 3rd month and of ITA on 6 month postoperatively in MV gr...

Nitrogen components of yoghurt milk samples and resulting probiotic set yoghurt weredetermined. Analyses included total nitrogen (TN), non-casein nitrogen (NCN), non-proteinnitrogen (NPN), casein nitrogen (CN) and proteolysis index (PI). Yoghurt samples wereanalyzed 1, 7, 14 and 21days after production and storage at 5±1°C. TN, CN and PI contentsof yoghurt milk samples with high Somatic Cell SC...

Twenty harpy eagles (Harpia harpyja) without systemic or ocular diseases were examined to measure blood velocity parameters of the pectinis oculi artery using Doppler ultrasonography. Pectinate artery resistive index (RI) and pulsatility index (PI) were investigated using ocular Doppler ultrasonography. The mean RI and PI values across all eyes were 0.44±0.10 and 0.62±0.20 respectively. Low RI ...

BACKGROUND A Giardia outbreak was associated with development of post-infectious functional gastrointestinal disorders (PI-FGID) and chronic fatigue syndrome (PI-CFS). Markers of immune dysfunction have given conflicting results in CFS and FGID patient populations. The aim of this study was to evaluate a wide selection of markers of immune dysfunction in these two co-occurring post-infectious s...

BACKGROUND Progressive beta-cell dysfunction and beta-cell failure are fundamental pathogenic consequences of type 2 diabetes. Dipeptidyl peptidase-IV inhibitors may exhibit improvement on preclinical measures of both beta-cell function, homeostasis model assessment of beta-cell (HOMA-beta) index, and beta-cell dysfunction, proinsulin/insulin ratio (PI/IR), correlating to beta-cell survival. ...

HIGHLIGHTS - Calmodulin-dependent Kv7.2 current density without the need of binding calcium.- Kv7.2 current density increase is accompanied with resistance to PI(4,5)P2 depletion.- Kv7.3 current density is insensitive to calmodulin elevation.- Kv7.3 is more sensitive to PI(4,5)P2 depletion in the presence of calmodulin.- Apo-calmodulin influences PI(4,5)P2 dependence in a subunit specific manne...