The blood-brain barrier prevents the entry of many therapeutic agents into the brain. Various nanocarriers have been developed to help agents to cross this barrier, but they all have limitations, with regard to tissue-selectivity and their ability to cross the endothelium. This study investigated the potential for 4 nm coated gold nanoparticles to act as selective carriers across human brain en...

BACKGROUND Exendin-4 is an incretin mimetic agent approved for type 2 diabetes treatment. However, the required frequent injections restrict its clinical application. Here, the potential use of chitosan-coated poly (d,l-lactide-co-glycolide) (CS-PLGA) nanoparticles was investigated for intestinal delivery of exendin-4. METHODS AND RESULTS Nanoparticles were prepared using a modified water-oil...

Ceria (CeO₂) nanoparticles have been widely studied for numerous applications, but only a few recent studies have investigated their potential applications in medicine. Moreover, there have been almost no studies focusing on their possible antibacterial properties, despite the fact that such nanoparticles may reduce reactive oxygen species. In this study, we coated CeO₂ nanoparticles with dextr...

in this study, fe 3 o 4 superparamagnetic nanoparticles were synthesized and stabilized by chitosan. then the nanoparticles were characterized by fourier transform infrared spectroscopy and transmission electron microscopy (tem). particle size distribution and zeta potential of the particles also was assessed using malvern zetasizer. the paramagnetic behaviors of the uncoated and chitosan coate...

Nanoparticulate zero-valent iron (nZVI) rapidly reacts with oxygen to produce strong oxidants capable of transforming organic contaminants in water. However,the low yield of oxidants with respect to the iron added normally limits the application of this system. Bimetallic nickel-iron nanoparticles (nNi-Fe; i.e., Ni-Fe alloy and Ni-coated Fe nanoparticles) exhibited enhanced yields of oxidants c...

Nanomaterials are being vigorously investigated for their use in anticancer drug delivery regimes or as biomarkers agents and are considered to be a candidate to provide a way to combat severe weaknesses of anticancer drug pharmacokinetics, such as their nonspecificity. Because of this weakness, a bigger proportion of the drug-loaded nanomaterials flow toward healthy tissues and result in undes...

A new intracellular mRNA imaging probe has been developed that incorporates thiol-terminated hairpin oligonucleotides covalently bound to the surface of citrate-capped gold nanoparticles. The hairpin DNA-coated gold nanoparticles (hAuNPs) positively identifies tyrosinase mRNA in cultured melanoma cells.

Carbon dots were used as a reducing agent for the synthesis of Pd nanoparticles coated with ultrathin carbon dot shells of ca. 4 nm. The resulting composite nanoparticles showed high catalytic activity for the Heck and Suzuki coupling reactions.

In this study, multi wall carbon nanotubes (MWCNTs) were synthesized by Chemical vapor deposition (CVD) method using two different catalysts (Fe nanoparticles) and (Ni nanoparticles) with  two different substrates: Quartz and Alumina. Acetylene gas was used as a carbon source and Argon as a carrier gas at different temperatures and different times to study the effects of these parameters on CNT...

In this study, multi wall carbon nanotubes (MWCNTs) were synthesized by Chemical vapor deposition (CVD) method using two different catalysts (Fe nanoparticles) and (Ni nanoparticles) with  two different substrates: Quartz and Alumina. Acetylene gas was used as a carbon source and Argon as a carrier gas at different temperatures and different times to study the effects of these parameters on CNT...