objective: neurocognitive deficits are now recognized as part of the fundamental disturbances and are a major determinant of functional outcome in psychosis. a cross-sectional association between cognitive deficits and poor social and occupational outcomes has been demonstrated; and treatment of cognitive impairment at the time of the first episode may have the potential to change functional ou...

Cognitive impairments are core symptoms of depressive disorders. We assess the systematic reviews and meta-analysis studies published over the last 10 years (2004-2014) that address cognitive performance of depressed patients and taking into account age; clinical and demographic features; symptom severity; number of previous episodes; clinical remission; depressive subtypes and pharmacological ...

................................................................................................. 5 Tiivistelmä ............................................................................................. 6 Acknowledgements ................................................................................ 8 List of original publications ..............................................................

donepezil, a member of the acetylcholinesterase inhibitor family, is approved for management of cognitive impairments as well as behavioral complications in patients with neurodegenerative alzheimer's disease. generally, donepezil is regarded as a safe medication in patients with alzheimer's disease although there have been reports of several minor adverse events including gastrointestinal dist...

BACKGROUND Cognitive function of Machado-Joseph disease (MJD) patients has not been clarified. OBJECTIVES To determine the characteristics of cognitive dysfunction in MJD patients and to assess the relationship of dysfunction to age at onset, age at examination, disease duration, education, ataxia, depression, anxiety, and CAG repeat length. DESIGN Case-control study. SETTING Research-ori...