OBJECTIVES Faecal serine proteases (FSPs) may play a role in irritable bowel syndrome with diarrhoea (IBS-D), but their origin is unclear. We aimed to structurally characterise them and define the impact of colonic cleansing and transit time. DESIGN Faecal samples were obtained from 30 healthy volunteers (HV) and 79 patients with IBS-D participating in a trial of ondansetron versus placebo. C...

PURPOSE Postoperative ileus (POI) is an impairment of coordinated gastrointestinal (GI) motility that develops as a consequence of abdominal surgery and is a major factor contributing to patient morbidity and prolonged hospitalization. The aim of this study was to investigate the effects of different 5-hydroxytryptamine 4 (5-HT₄) receptor agonists, which stimulate excitatory pathways, on a POI ...

Introduction: The dwell time and transit time components contribute to the overall delivered dose to patients in high dose rate (HDR) brachytherapy treatments. The transit time results from source entry and exit as well as source movements between dwell positions. It depends on various parameters such as the source speed profile, source indexer distance to dwell position, and ...

The colon serves to absorb fluid and electrolytes, to mix its contents, to store its contents and to empty it in a controlled fashion. Motility, absorption and secretion closely interact to fulfil these functions. Tone, phasic contractions and ano-rectal closure are the main principles of colonic motility. They are controlled by the enteric nervous system. Colonic motility differs from that in ...

Colonic motility is modulated by the 5-hydroxytryptamine (5-HT)(3)-dependent gastrocolonic response and 5-HT(3)-independent peristaltic reflex. We compared descending colon tone responses to antral distension, duodenal lipid perfusion, and colonic distension after double-blind placebo or granisetron in 13 healthy volunteers and nine slow-transit constipated patients. Antral distension (100-300 ...

BACKGROUND Existing data on the effect of ageing on gastrointestinal motility are few. In this study, we assessed the propulsive effect of all main segments of the gastrointestinal tract in a group of healthy older people. METHODS 16 healthy volunteers (eight women, eight men) of mean age 81 years (range 74-85 years) participated in the study. Gastric emptying and small intestinal and colonic...

Introduction: Renal dynamic study is a well-established and popular test in routine practice of nuclear medicine. The test is non-invasive, rapid and unique in evaluation of the kidney function. In despite of its clinical values, the parameters derived from renogram are physiologically meaningless. That is due to the fact that renogram is not the true kidney function. From mathematical po...

introduction: renal dynamic study is a well-established and popular test in routine practice of nuclear medicine. the test is non-invasive, rapid and unique in evaluation of the kidney function. in despite of its clinical values, the parameters derived from renogram are physiologically meaningless. that is due to the fact that renogram is not the true kidney function. from mathematical points o...

Description of Procedure or Service An ingestible pH and pressure-sensing capsule (SmartPill® GI Monitoring System) measures pH, pressure, and temperature changes to signify passage of the capsule through portions of the gastrointestinal tract. It is proposed as a means of evaluating gastric emptying for diagnosis of gastroparesis, and colonic transit times for the diagnosis of slow-transit con...

colon transit time study with radio opaque markers is a simple method for assessment of colon motility disorder in patients with chronic idiopathic constipation. appendicitis caused by metallic objects has been reported repeatedly and is very important because of its complications. we report a case of acute appendicitis that was induced by impaction of radio opaque markers after colon transit t...