Introduction: Colorectal carcinoma is primary epithelial malignancy arising in the colorectum areas. 98% of colonic and rectum cancers are adenocarcinomas. The prevalence colorectal cancer has been dramatically growing at an alarming rate globally recent years. Materials methods: This retrospective study Department Pathology B P Koirala Memorial Cancer Hospital effective from 1st January 2018 t...

Background: Small intestine cancers, as an extremely rare tumor type, account only for 3% of all gastrointestinal tumors. adenocarcinoma (SIA), representing approximately one-third small bowel has received relatively little attention, both in research efforts and clinical cognizance. Owing to anatomical proximity rarity, adenocarcinomas are frequently grouped with colorectal adenocarcinomas. Th...

Growing evidence has shown that long non-coding RNAs (lncRNAs) can serve as prospective markers for survival in patients with colorectal adenocarcinoma. However, most studies have explored a limited number of lncRNAs in a small number of cases. The objective of this study is to identify a panel of lncRNA signature that could evaluate the prognosis in colorectal adenocarcinoma based on the data ...

BACKGROUND Gastric cancer is one of the most common malignancies in the world and is the second most common cause of cancer-related death in Korea. Colorectal metastases from gastric adenocarcinoma are known to be very rare. We report an unusual case of rectal metastasis of gastric adenocarcinoma. CASE PRESENTATION We report a case of a 43-year-old female patient with gastric cancer who first...

FGFR2 is recurrently amplified in 5% of gastric cancers and 1%-4% of breast cancers; however, this molecular alteration has never been reported in a primary colorectal cancer specimen. Preclinical studies indicate that several FGFR tyrosine-kinase inhibitors (TKIs), such as AZD4547, have in vitro activity against the FGFR2-amplified colorectal cell line, NCI-H716. The efficacy of these inhibito...

INTRODUCTION It is generally accepted that mitochondria are a primary source of intracellular reactive oxygen species (ROS). Under physiological circumstances they are permanently formed as by-products of aerobic metabolism in the mitochondria. To counter the harmful effect of ROS, cells possess an antioxidant defence system to detoxify ROS and avert them from accumulation at high concentration...

In the normal intestinal epithelium transforming growth factor B-1 (TGFB-1) acts as a growth inhibitor, but in malignant cells it may act as a tumor promoter. However, only limited information is available on genetic variation in the TGFB1 gene and its relationship to circulating levels and risk of colorectal cancer. To characterize associations of genetic variation [tagging single-nucleotide p...

RATIONALE DNA damage and chromosomal alterations in peripheral lymphocytes parallels DNA mutations in tumor tissues. OBJECTIVE The aim of our study was to predict the presence of neoplastic colorectal lesions by specific biomarkers in "medium risk" individuals (age 50 to 75, with no personal or family of any colorectal neoplasia). METHODS AND RESULTS We designed a prospective cohort observa...

BACKGROUND Aurora kinase A (AURKA), or STK15/BTAK, is a member of the serine/threonine kinase family and plays important roles in mitosis and chromosome stability. This study investigated the clinical significance of AURKA expression in colorectal cancer patients in Korea. METHODS AURKA protein expression was evaluated by immunohistochemistry in 151 patients with colorectal adenocarcinoma usi...

Aim: The identification of cellular pathways in colorectal tumor biology is essential for early diagnosis, treatment, and post-treatment follow-up. Osteopontin an extracellular matrix protein that has regulatory physiological functions roles apoptosis, proliferation, adhesion, invasion, metastasis. In this study, we aimed to determine the prognostic predictive value osteopontin colon adenocarci...