BACKGROUND To evaluate the efficacy and safety of glyburide/metformin combined tablet compared to glyburide or metformin alone in patients with type 2 diabetes. METHODS In this 16-week, multicenter, randomized, double-blind, 4-arm and parallel clinical trial study, 100 patients with type 2 diabetes mellitus were recruited and 76 patients were available for statistical analysis at the end of t...

BACKGROUND Olaparib (Lynparza) is an oral poly(adenosine diphosphate [ADP]-ribose) polymerase inhibitor that induces synthetic lethality in cancers with homologous recombination defects. PATIENTS AND METHODS In this phase I, dose-escalation trial, patients with advanced solid tumours received olaparib (50-200 mg capsules b.i.d.) continuously or intermittently (days 1-14, per 28-day cycle) plu...

Abstract Chemical mapping by Raman spectroscopy is widely used in the pharmaceutical industry to characterise distribution of components within tablets; however, current methods do not go beyond examining an exposed surface area a sample. There are known limitations with estimating domain size and shape statistics from 2D chemical images as values obtained will depend on where sectioned, potent...

A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. In this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (EC), Eudragit RS100 (RS), and Eudragit S100 (S) were prepared by direct compression. The release behaviors were then studied in two co...

Aluminum phosphide (AlP) is an important fumigant, a commendable and very effective outdoor and indoor insecticide. AlP, locally named “rice tablet”, is widely used to protect rice. As soon as taking a very small amount of an AlP tablet, phosphine vaporizes due to the exposure to the air and affects different kinds of organs. Although, in most cases, clinical history can help making the final d...

Tablet in tablet formulation, containing Aceclofenac (API) in core tablet and coated with hydroxylpropyl cellulose (HPC) was evaluated for time drug release with predetermined lag time and subsequent rapid release phase. Various types of press coated tablets were prepared using single punch tablet machine. They were evaluated for various physicochemical properties and in vitro dissolution study...

Prediction using pure standards is expected to be biased whenever the slope of the calibration is affected by the presence of sample matrix. Moreover, in the presence of unknown spectral interferents, first-order algorithms like partial least squares cannot be used. In this study, a method for determination of carvedilol (CAR) in tablet and urine samples is proposed by excitation-emission fluor...

In this study Fusion Deposition Modelling (FDM) was employed to design and fabricate a bilayer tablet consisting of isoniazid (INZ) rifampicin (RFC) for the treatment tuberculosis. INZ formulated in hydroxypropyl cellulose (HPC) matrix allow drug release stomach (acidic conditions) RFC hypromellose acetate succinate (HPMC – AS) upper intestine (alkaline conditions). This may offer better clinic...