To gain insight into the conformational properties and compaction of megabase-long chromatin molecules, we reconstituted chromatin from T4 phage DNA (165 kb) and recombinant human histone octamers (HO). The unimolecular compaction, induced by divalent Mg2+ or tetravalent spermine4+ cations, studied by single-molecule fluorescence microscopy (FM) and dynamic light scattering (DLS) techniques, re...

Compactions are a vital maintenance mechanism used by datastores based on the log-structured merge-tree to counter the continuous buildup of data files under update-intensive workloads. While compactions help keep read latencies in check over the long run, this comes at the cost of significantly degraded read performance over the course of the compaction itself. In this paper, we offer an in-de...

In this paper, we discuss some novel techniques for modeling sedimentation and compaction using fully unstructured meshes. The numerical modeling of the sedimentation process is a critical part of basin simulation and synthetic stratigraphy modeling. Normally, structured curvilinear meshes are used to represent sedimentary sequences to be deposited during the simulation. Using this approach, 2D...

The histone-like nucleoid structuring protein (H-NS) is a nucleoid-associated protein, which is involved in both gene regulation and DNA compaction. H-NS can bind to DNA in two different ways: in trans, by binding to two separate DNA duplexes, or in cis, by binding to different sites on the same duplex. Based on scanning force microscopy imaging and optical trap-driven unzipping assays, it has ...

BACKGROUND Isolated left ventricular non-compaction (LVNC) is an uncommon disorder characterized by the presence of increased trabeculations and deep intertrabecular recesses. In adults, it has been found that ejection fraction (EF) decreases significantly as non-compaction severity increases. In children however, there are a few data describing the relation between anatomical characteristics o...

I magine a society with perfect economic equality. Perhaps out of sheer coincidence, the supply and demand for different types of labor happen to produce an equilibrium in which everyone earns exactly the same income. As a result, no one worries about the gap between the rich and poor, and no one debates to what extent public policy should make income redistribution a priority. Because people e...

That tired Ten-Percent claim pops up all the time. Last year, national magazine ads for U.S. Satellite Broadcasting showed a drawing of a brain. Under it was the caption, "You only use 11 percent of its potential." Well, they're a little closer than the ten-percent figure, but still off by about 89 percent. In July 1998, ABC television ran promotional spots for "The Secret Lives of Men," one of...

An information retrieval performance measure that is interpreted as the percent of perfect performance (PPP) can be used to study the effects of the inclusion of specific document features or feature classes or techniques in an information retrieval system. Using this, one can measure the relative quality of a new ranking algorithm, the result of incorporating specific types of metadata or folk...

introduction: root canal obturation seals the root canal system to prevent re-entry and/or growth of microorganisms. the provision of an appropriate restoration to coronally seal the access cavity affects the success of endodontic treatment. the purpose of this study was to evaluate the coronal microbial leakage in root canals that were either filled by lateral compaction, guttaflow or warm ver...