نتایج جستجو برای: complement dependent lymphocytotoxicity cdc
تعداد نتایج: 759890 فیلتر نتایج به سال:
The epidermal growth factor receptor (EGFR), a molecule that is highly expressed in epithelial tumors, provides a clinically validated target for anti-cancer drug development. Anti-EGFR passive agents have shown anti-tumor activity in pre-clinical and clinical trials; optimization of these therapies is currently under active research. So far, no clear association between EGFR expression levels ...
Blood platelets are involved in a number of immune reactions and, by release of vasoactive amines and thromboplastic factor(s), may contribute to vascular injury and deposition of fibrin (1, 2). Platelet injury can be induced by bacterial endotoxins (3, 4) and immune complexes (5-7), both of which require complement, and by membrane-active bacterial toxins such as streptolysins O and S and stap...
The concept of elicitation of reactions of anaphylactic type by non-tissue-fixing antibody, through activation of complement and release of anaphylatoxins by antigen-antibody complexes in vivo, is not clearly defined by published evidence. Experimental data are presented to demonstrate that guinea pig immunoglobulin G2 (noncytotropic) complexed with antigen in vitro elicits dermal reactions in ...
two groups of antibodies against mouse resident alveolar and peritoneal macrophages have been raised individually in rabbits by immunization with whole cell suspensions of lavaged alveolar and peritoneal macrophages. the whole antisera reacted positively with neutrophils and lymphocytes. however, upon extensive absorptions with these cells the activity became restricted to macrophages. the immu...
Results Anti-CD20-hIFNa induced stronger growth inhibition than rituximab, particularly against Burkitt and germinal center-type DLBCL NHLs. Tumor growth inhibition by anti-CD20-hIFNa was associated with substantial apoptosis in some cell lines. Anti-CD20-hIFNa exhibited potent ADCC activity against Daudi, Ramos, and Raji cells, identical to rituximab. Surprisingly, anti-CD20-hIFNa exhibited su...
BACKGROUND Traditional influenza surveillance relies on influenza-like illness (ILI) syndrome that is reported by health care providers. It primarily captures individuals who seek medical care and misses those who do not. Recently, Web-based data sources have been studied for application to public health surveillance, as there is a growing number of people who search, post, and tweet about thei...
WE have. observed that FK S06 (FK) preve~ted the inductIon of hyperacute reJectIOn (HAR) In hamster-to-ratliver (OLTX) and heart (HTX) transplant models and analyzed the mechamsms. 1.5 x 107 hamster hepatocytes (HC) or a minced heart as source of xenoantigens were given to prospective recipients on day -6. with or without FK (I mg/kg/d x fl). OL TX and HTX were performed on day O. Xenoantigen a...
The development of solid-phase assays for antibody detection has aided in the frequent detection of human leukocyte antigen (HLA) antibodies in nonalloimmunized males. Some scientists have reported that these HLA antibodies are produced to pathogens or allergens and the reactivity with HLA coated beads is the result of cross-reactive epitopes. These antibodies may also be directed toward crypti...
Proteins containing membrane attack complex/perforin (MACPF) domains play important roles in vertebrate immunity, embryonic development, and neural-cell migration. In vertebrates, the ninth component of complement and perforin form oligomeric pores that lyse bacteria and kill virus-infected cells, respectively. However, the mechanism of MACPF function is unknown. We determined the crystal struc...
Organ donors are sometimes found "unsuitable" due to the presence of donor-specific anti-HLA antibodies in the recipient. In recent years, improved desensitization protocols have successfully helped to overcome HLA incompatibility hurdle. We present three cases where optimum desensitization was achieved in patients with the donor-specific anti-HLA antibody (DSA) leading to successful renal tran...
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