The complex process of apoptosis is orchestrated by caspases, a family of cysteine proteases with unique substrate specificities. Accumulating evidence suggests that cell death pathways are finely tuned by multiple signaling events, including direct phosphorylation of caspases, whereas kinases are often substrates of active caspases. Importantly, caspase-mediated cleavage of kinases can termina...

Abstract Non-ribosomal peptide synthetases are important enzymes for the assembly of complex natural products. Within these multi-modular lines, condensation domains perform central function chain assembly, typically by forming a bond between two peptidyl carrier protein (PCP)-bound substrates. In this work, we report structural snapshots domain in with an aminoacyl-PCP acceptor substrate. Thes...

Both β-amyloid (Aβ) peptides and oxidative stress conditions play key roles in Alzheimer’s disease. Hemin contributes to the development of disease as it possesses redox properties its level increases pathological or traumatic brain injuries. The aim this work was deepen investigation reactivity hemin–Aβ16 complex, considering ability catalyze oxidation nitration reactions. We performed kinetic...