To increase knowledge of leptospirosis in the Netherlands and identify changing trends of this disease over time, we analyzed historical passive surveillance reports for an 84-year period (1925-2008). We found that 2,553 mainly severe leptospirosis cases were diagnosed (average annual incidence rate 0.25 cases/100,000 population). The overall case-fatality rate for patients with reported leptos...

Symptoms of the early phase leptospirosis often are non-specific and can be a major problem in making a diagnosis of febrile illnesses. Rapid diagnosis of leptospirosis is of extreme importance, because antibiotic treatment provides greatest benefit when administered in early stage of the disease. Recombinant flagellin B (FlaB) gene (flaB) of Leptospira interrogans serovar Autumnalis strain Aki...

Abstract Kawasaki disease (KD) is a vasculitis that mostly occurs in children, but rare cases adults have been reported. We describe the case of 43-year-old Swiss male who developed symptoms compatible with KD 7 weeks after leptospirosis, which was presumably acquired swimming creek Alps. performed literature review and identified 10 other (all children), Kawasaki-like diagnosed context leptosp...

Leptospirosis is a spirochetal bacterial infection of great public health importance. It has a broad spectrum of clinical manifestations which goes from subclinical infection and self-limited anicteric febrile illness (80-90% of all cases) to icteric leptospiropirosis known as Weil's disease. This is a severe disease characterized by hemorrhage, acute renal failure and jaundice. It is uncommon ...

Leptospirosis is a globally important zoonotic disease, most commonly founded in tropical or sub-tropical countries. Leptospirosis is an acute febrile illness caused by pathogenic members of the genus Leptospira. The present study was done to evaluate the prevalence and other variables related to Leptospirosis in Mazandaran province (north of Iran) during 2010. Blood samples were collected from...

In this paper we develop and analyze the model for the spread of Leptospirosis by age group in Thailand, between 1997 and 2010 by using mathematical modeling and computer simulation. Leptospirosis is caused by pathogenic spirochetes of the genus Leptospira. It is a zoonotic disease of global importance and an emerging health problem in Thailand. In Thailand, leptospirosis is a reportable diseas...

Pancytopaenia is a rare clinical presentation of severe leptospirosis. We would like to report a case of severe leptospirosis that progressed to pancytopaenia despite initial penicillin therapy. The patient needed a second course of antibiotic with doxycycline to improve his persistent symptoms and cytopaenia. Persistent pancytopaenia in severe leptospirosis and its management were reviewed.

Timely diagnosis of leptospirosis is important to ensure a favorable clinical outcome. The definitive serologic assay, the microscopic agglutination test (MAT), requires paired sera and is not useful for guiding early clinical management. The only screening test approved for use in the United States, the indirect hemagglutination assay (IHA), has not undergone extensive field evaluation. To ass...

BACKGROUND Dogs with leptospirosis show similar organ manifestations and disease course as human patients, including acute kidney injury and pulmonary hemorrhage, making this naturally-occurring infection a good animal model for human leptospirosis. Expression patterns of cytokines and enzymes have been correlated with disease manifestations and clinical outcome in humans and animals. The aim o...

Leptospirosis hingga saat ini masih menjadi problematika kesehatan di seluruh dunia terutama negara tropis dan subtropis salah satunya Indonesia. Manusia dapat terjangkit leptospirosis akibat kontak dengan lingkungan. Penelitian bertujuan untuk mengetahui pengaruh faktor lingkungan abiotik sebagai sumber penularan leptopspirosis Studi merupakan literature review metode PRISMA. Kata kunci yang d...