The purpose of this study was to reduce the radiation dosage associated with computed tomography (CT) lung cancer screening while maintaining overall diagnostic image quality and definition of ground-glass opacities (GGOs). A lung screening phantom and a multipurpose chest phantom were used to quantitatively assess the performance of two iterative image reconstruction algorithms (adaptive stati...

PURPOSE To evaluate the clinical benefit of using a new iterative reconstruction technique fully integrated on a standard clinical scanner and reconstruction system using a TWIST acquisition for high-resolution dynamic three-dimensional contrast-enhanced MR angiography (CE-MRA). METHODS Low-dose, high-resolution TWIST datasets of 11 patients were reconstructed using both standard GRAPPA-based...

Angiographic C-arm systems are capable of performing computed tomography (CT) imaging for assisting in therapy planning, performance and assessment. Due to the long acquisition time, C-arm CT of dynamic structures is challenging. Cardiac motion has to be estimated and compensated in the reconstruction step. The quality of the motion estimation algorithm mainly dictates the resulting image quali...

While conventional wisdom is that the interior problem does not have a unique solution, by analytic continuation we recently showed that the interior problem can be uniquely and stably solved if we have a known sub-region inside a region of interest (ROI). However, such a known sub-region is not always readily available, and it is even impossible to find in some cases. Based on compressed sensi...

Cardiac single photon emission computed tomography (SPECT) cameras typically rotate too slowly around a patient to capture changes in the blood pool activity distribution and provide accurate kinetic parameters. A spatiotemporal iterative reconstruction method to overcome these limitations was investigated. Dynamic rest/stress (99m)Tc-methoxyisobutylisonitrile ((99m)Tc-MIBI) SPECT/CT was perfor...

Cardiac computed tomography (CT) is important for its use in diagnosing heart disease. Motion artifacts are a significant issue for cardiac CT image reconstruction. Motioncompensated image reconstruction (MCIR) has the potential to overcome the drawbacks of conventional gated reconstruction methods by exploiting all the measurement data and using motion information. However, MCIR methods are co...

Differential X-ray phase-contrast tomography (DPCT) refers to a class of promising methods for reconstructing the X-ray refractive index distribution of materials that present weak X-ray absorption contrast. The tomographic projection data in DPCT, from which an estimate of the refractive index distribution is reconstructed, correspond to one-dimensional (1D) derivatives of the two-dimensional ...

Introduction: To investigate the effects of breathing cycle and tree diaphragm motions on prostate cancer tumors standard uptake value (SUV) during positron emission tomography (PET) and to correct it. Materials and methods: Respiratory motion traces were simulated on the common patient breathing cycle and tree diaphragm motio...