The glucocorticoid receptor (GR), like other eukaryotic transcription factors, regulates gene expression by interacting with chromatinized DNA response elements. Photobleaching experiments in living cells indicate that receptors transiently interact with DNA on the time scale of seconds and predict that the response elements may be sparsely occupied on average. Here, we show that the binding of...

This paper proposes a transmission scheduling algorithm for interference management in broadband wireless access networks. The algorithm aims at minimizing the cochannel interference using basestation coordination while still maintaining the other quality of service (QoS) requirements such as packet delay, throughput, and packet loss. The interference reduction is achieved by avoiding (or minim...

The link between compensatory dynamics and regime shifts is not well understood. We analyse a regime shift in phytoplankton in a large lake with respect to: (1) environmental forcing and (2) the type of dynamics (compensatory or synchronous) between phytoplankton groups. The regime shift in phytoplankton was related to gradual changes in nutrient levels, but unrelated to an almost concurrent sh...

The use of mice to study models of human disease has resulted in a surge of interest in developing mouse MRI. The ability to take 3D, high-resolution images of live mice allows significant insight into anatomy and function. However, with imaging times on the order of hours, high throughput of specimens has been problematic. To facilitate high throughput, concurrent imaging of multiple mice has ...

The Oberon programming language and system, subsequently called the Oberon technology, are well known in the software research community. Few applications, however, exist outside academic institutions. This paper describes one of them (FFF97), which constitutes a database front end application that has been in mission critical use by more than 25 concurrent users since 1998. FFF97 makes full us...

mild congestive phenomena. In such cases it appears justifiable to rely upon physiotherapeutic measures while in bed, and early ambulation, to prevent venous thromboembolism. In the case of older patients with severe congestive failure, however, oral anticoagulant drug therapy can be expected to prevent venous thromboembolism after the second week, and such prophylaxis is clearly indicated if i...

A circular argument has been developed and further propagated through a series of studies that link a major climate-modifying eruption in the 15 th century with Kuwae caldera in Vanuatu. Clear evidence in both N and S hemispheres suggests a major eruption with global atmospheric sulphur loading occurred in 1455-56. Concurrent 14 C determinations from pyroclastic units and estimations of caldera...

Controvery exists as to how fatigue can influence lifting biomechanics. Lifters have decreased their range of motion (ROM) at the hip and knee [1] and increased their flexion ROM at the trunk [2], while other lifters have responded oppositely, where hip ROM was increased and trunk ROM decreased concurrent with a decrease in moment loading on the spine, as a function of time [3]. It remains clea...

The study describes the acoustic emission (AE) activity during human femur tissue fracture. The specimens were fractured in a bending-torsion loading pattern with concurrent monitoring by two AE sensors. The number of recorded signals correlates well with the applied load providing the onset of micro-fracture at approximately one sixth of the maximum load. Furthermore, waveform frequency conten...

When people monitor the rapid serial visual presentation (RSVP) of stimuli for two targets (T1 and T2), they often miss T2 if it falls into a time window of about half a second after T1 onset, a phenomenon known as the attentional blink (AB). We found that overall performance in an RSVP task was impaired by a concurrent short-term memory (STM) task and, furthermore, that this effect increased w...