we studied the immune system, especially the chemotactic activity of neutrophils, in ten patients with vitamin d-deficient rickets and compared the results with ten healthy controls of matched age. among all immune system factors, the chemotactic studies persistantly showed remarkable deficiency in leukocyte mobility, both random motion and migration. when compared with controls, the findings w...

Ethnic minorities in Britain having their origins in the West Indies, the Indian sub-continent (Asian), China and Africa consume diets which differ in varying degree from those of the indigenous population. These minority groups are in general well nourished and almost certainly share obesity with the host population as their commonest nutritional problem. Infantile rickets and iron deficiency ...

Caroli’s disease and Caroli’s syndrome are rare congenital cystic disorders of intrahepatic biliary radicals. It is still unclear whether they represent distinct entities or, are different stages of the same disease distinguished by hepatic fibrosis. Here we are reporting two cases-a three-year-old boy presenting with portal hypertension, cholestatic jaundice and rickets, and a ten-year-old gir...

Introduction Vitamin D deficiency is the major cause of rickets and osteomalacia, bone diseases which lead to several deformities of the skeleton. This paper gives a review about skeletal evidence of both diseases in Europe. First, it is necessary to explain the main principles of vitamin D metabolism in order to understand causes and effects of vitamin D deficiency. These aspects are followed ...

A 12-week-old domestic cat presented at a local veterinary clinic with hypocalcemia and skeletal abnormalities suggestive of rickets. Osteomalacia (rickets) is a disease caused by impaired bone mineralization leading to an increased prevalence of fractures and deformity. Described in a variety of species, rickets is most commonly caused by vitamin D or calcium deficiencies owing to both environ...

Vitamin D deficiency remains a global, public health concern despite intense focus in recent years. While nuanced issues such as the most appropriate cut-offs to define degrees of vitamin D sufficiency, insufficiency and deficiency are still unsettled, these debates occur on a backdrop of children continuing to be diagnosed around the world with the most devastating consequences of overt vitami...

BACKGROUND There is no local data about rickets available in Hazara Division, while clinical experience suggests that problem exists in this area with abundant sunlight. We carried out this study with an objective to determine presence, presentation and predisposing factors of rickets in pediatrics population of Hazara Division. METHODS This study was conducted in Department of Pediatrics, Ay...

Abstract Lowe syndrome (LS) is a rare X-linked condition having clinical triad of congenital cataracts, intellectual disability, and progressive tubular nephropathy. Although the easily recognizable symptom complex usually evolves by infancy, unifying diagnosis often missed. We present young boy with prolonged history multisystem affection, finally leading to suspicion LS. The was confirmed on ...

Secondary hyperparathyroidism is an unusual complication of hypophosphatemic rickets during the treatment. As there is growing evidence that a high phosphate diet may induce secondary hyperparathyroidism and even tertiary hyperparathyroidism caused by hyperplasia of the parathyroid glands. Serum calcium, phosphate and also parathyroid hormone should be measured regularly to catch the early diag...