The HAMP linker, a predicted structural element observed in sensor proteins from all domains of life, is proposed to transmit signals between extracellular sensory input domains and cytoplasmic output domains. HAMP (histidine kinase, adenylyl cyclase, methyl-accepting chemotaxis protein, and phosphatase) linkers are located just inside the cytoplasmic membrane and are projected to form two shor...

Although health insurance exchanges are a growing source of individual coverage, little is known about consumer behavior on these exchanges. While health insurance exchanges are intended to facilitate competition among insurers and make it easier for consumers to access insurance, understanding how consumers choose insurance plans is necessary for the design of these markets. We characterize de...

A kind of lattice-type steel member is presented and a prefabricated connector suitable for the connection between members are proposed. The mechanical properties connectors analyzed by using finite element numerical simulation software ABAQUS. meet design goals stiffness stronger than members. Parameterized analysis carried out on connector, flexural expression obtained. suggested values each ...

Functional selectivity is a property of G protein-coupled receptors that allows them to preferentially couple to particular signaling partners upon binding of biased agonists. Publication of the X-ray crystal structure of serotonergic 5-HT1B and 5-HT2B receptors in complex with ergotamine, a drug capable of activating G protein coupling and β-arrestin signaling at the 5-HT1B receptor but clearl...

Interoperability of heterogeneous networked systems has yet to reach the maturity required by ubiquitous computing due to the technology-dependent nature of solutions. The Connect Integrated Project attempts to develop a novel network infrastructure to allow heterogeneous networked systems to freely communicate with one another by synthesising the required connectors on-the-fly. A key objective...

................................................ 3 Acknowledgements ...................................................................................................................... 4 Table of