Introduction Osteoarthritis (OA) is a highly prevalent joint disease. Obesity is one of the most important risk factors of new-onset OA and deterioration of OA. Obesity was once considered to cause OA simply by added mechanical force. Yet, more recent studies have shown that metabolic factors produced by fat tissue can also initiate inflammatory cascade that consequently can lead to OA. This is...

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The human–computer interaction (HCI) design of educational technologies influences cognitive behaviour, so it is imperative to assess how different HCI strategies support intended behaviour. We developed a neuroscience-inspired game that trains children's use “stopping-and-thinking” (S&T)—an inhibitory control-related behaviour—in the context counterintuitive science problems. tested effica...

Despite prevention efforts, burn injuries among auto mechanics are described in the literature. Electrothermal ring burns from car batteries occur by short-circuiting through the ring when it touches the open terminal or metal housing. This article describes a 34-year-old male auto mechanic who was holding a wrench when his gold ring touched the positive terminal of a 12-volt car battery and th...

The Hippo pathway is crucial in organ size control, whereas its dysregulation contributes to organ degeneration or tumorigenesis. The kinase cascade of MST1/2 and LATS1/2 and the coupling transcription co-activators YAP/TAZ represent the core components of the Hippo pathway. Extensive studies have identified a number of upstream regulators of the Hippo pathway, including contact inhibition, mec...