BACKGROUND The Orf virus (ORFV), a zoonotic Parapoxvirus, causes pustular skin lesions in small ruminants (goat and sheep). Intriguingly, ORFV can repeatedly infect its host, despite the induction of a specific immunity. These immune modulating and immune evading properties are still unexplained. RESULTS Here, we describe that ORFV infection of permissive cells impairs the intracellular trans...

Brucellosis is a highly contagious zoonosis that affects the public health and economic performance of endemic as well as non-endemic countries. In developing nations, brucellosis is often a very common but neglected disease. The purpose of this review is to provide insight about brucellosis in animal populations in Egypt and help to understand the situation from 1986 to 2013. A total of 67 nat...

Orf virus (ORFV) is a parapoxvirus that infects sheep, goats and man. In humans, the virus induces acute, pustular skin lesions that can develop into a progressive disease. Humans are susceptible to reinfection with ORFV and rare cases of persistent infection have been reported. ORFV encodes several immunomodulators, including a homologue of interleukin-10 (ORFV IL-10), that may explain these p...

BACKGROUND Scabies, a highly pruritic and contagious mite infestation of the skin, is endemic among tropical regions and causes a substantial proportion of skin disease among lower-income countries. Delayed treatment can lead to bacterial superinfection, and treatment of close contacts is necessary to prevent reinfestation. We describe scabies incidence and superinfection among children in Amer...

BACKGROUND Contagious ovine digital dermatitis (CODD) is an important cause of infectious lameness in sheep in the UK and Ireland and has a severe impact on the welfare of affected individuals. The three treponemal phylogroups Treponema medium/Treponema vincentii-like, Treponema phagedenis-like and Treponema pedis spirochaetes have been associated with clinical CODD lesions and are considered t...

ii To my husband Peter for his patience and love To my parents for their continual support and unconditional love To my family, friends and classmates To my mentors and committee for their guidance and support iii ACKNOWLEDGMENTS I would like to express my deepest gratitude to Dr. Marcos Vargas for his unconditional availability, caring support, encouragement and his desire to share his knowled...

© 2012 The Authors. doi: 10.2340/00015555-1167 Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Penile pyoderma gangrenosum (PPG) is an uncommon, non-infectious and idiopathic skin disease. Therapeutic options include topical or systemic corticosteroids or other systemically administered immunomodulatory drugs (1). We described here an eruption of pustular PPG, which was tr...

BACKGROUND Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity disorder induced by Aspergillus species colonizing the bronchial tree. There are patients with asthma who fulfill the diagnostic criteria of ABPA by serologic evaluation (specific IgE/IgG to Aspergillus fumigatus), bronchography, CT, and or conventional linear tomography. OBJECTIVE To identify different forms of A...

Dr George Percival joined the consultant staff when the new building was opened in 1936. Trained in Paris, Lausanne, and Zurich, he knew as well as Dr Jamieson how to deal with leg eczema. Sir Robert Grant, the head of a family already lavishly generous to the University of Edinburgh, was aware of the damage that skin disease could do to his employees, and was unhappy when he developed eczema o...