the data set used in this study contained 8793 records of lamb's longevity (days) from 320 sires and 2349 dams collected during 1989 to 2014, from the lori-bakhtiari flock at shooli station in shahrekord, iran. genetic parameters (partitioned into autosomal, sex-linked and maternal) and breeding values of cumulative lamb's longevity from birth up to yearling age (at 1, 2, 3, 6, 9 and ...

Dominance has been suggested as one of the genetic mechanisms explaining heterosis. However, using traditional quantitative genetic methods it is difficult to obtain accurate estimates of dominance effects. With the availability of dense SNP (Single Nucleotide Polymorphism) panels, we now have new opportunities for the detection and use of dominance at individual loci. Thus, the aim of this stu...

Borderline personality disorder is a severe personality disorder for which genetic research has been limited to family studies and classical twin studies. These studies indicate that genetic effects explain 35 to 45% of the variance in borderline personality disorder and borderline personality features. However, effects of non-additive (dominance) genetic factors, non-random mating and cultural...

Despite considerable success of genome wide association (GWA) studies in identifying causal variants for many human diseases, their success in unraveling the genetic basis to complex diseases has been more mitigated. Pathogen population structure may impact upon the infectious phenotype, especially with the intense short-term selective pressure that drug treatment exerts on pathogens. Rigorous ...

Evolution of size and growth depends on heritable variation arising from additive and maternal genetic effects. Levels of heritable (and nonheritable) variation might change over ontogeny, increasing through "variance compounding" or decreasing through "compensatory growth." We test for these processes using a meta-analysis of age-specific weight traits in domestic ungulates. Generally, mean st...

Reproductive data (N=7152 sows with 8787 records) were used to estimate breeding values for total litter size under a model fitting both additive and social genetic effects. Pregnancy tested sows which failed to farrow (<1% of records) were allocated trait values of 0. Sows were penned into 1504 groups of between 2 to 10 sows/group during gestation. Seven subsets of data containing a single rec...

Sexual dimorphism in genetic parameters is examined for wing dimensions of Drosophila melanogaster. Data are fit to a quantitative genetic model where phenotypic variance is a linear function of additive genetic autosomal variance (common to both sexes), additive genetic X-linked variances distinct for each sex, variance due to common rearing environment of families, residual environmental vari...

We report the effect of major catecholamine metabolites such as homovanillic acid and vanilmandelic acid, normally present in urine, on quantitation of urinary uric acid by the direct acid ferric-reduction procedure [(Am. J. Clin. Pathol. 60, 691 (1973)]. When aqueous uric acid standards containing a mixture of these two metabolites, in concentrations comparable to those in a normal human 24-h ...

Estimates of genetic parameters resulting from three different models for birth weight, weaning weight, yearling weight and total gain were compared. Data consisted of 823 Holstein-Friesian animals progenies of 25 sires and 459 dams in a single herd. The MTDFREML programs were used to estimate heritabilities, predicted transmitting abilities (PTA) and genetic correlations. The three models comp...

Direct and maternal breed effects on birth and 200-d weights were estimated for nine parental breeds (Hereford [H], Angus [A], Braunvieh [B], Limousin [L], Charolais [C], Simmental [S], Gelbvieh [G], Red Poll [R], and Pinzgauer [P]) that contributed to three composite populations (MARC I = 1/4B, 1/4C, 1/4L, 1/8H, 1/8A; MARC II = 1/4G, 1/4S, 1/4H, 1/4A; and MARC III = 1/4R, 1/4P, 1/4H, 1/4A). Re...