Transcription factors are important gene regulators with distinctive roles in development, cell signaling and cell cycling, and they have been associated with many diseases. The ConTra v2 web server allows easy visualization and exploration of predicted transcription factor binding sites in any genomic region surrounding coding or non-coding genes. In this new version, users can choose from nin...

Transcription factors (TFs) are key components in signaling pathways, and the presence of their binding sites in the promoter regions of DNA is essential for their regulation of the expression of the corresponding genes. Orthologous promoter sequences are commonly used to increase the specificity with which potentially functional transcription factor binding sites (TFBSs) are recognized and to ...

Unsteady mixed convection heat transfer from a circular cylinder has been investigated in the presence of viscous dissipation. The isothermal horizontal cylinder is placed to the oncoming free stream whose direction is considered in the free convection flow (parallel flow) and opposite to it (contra flow). The system of dimensionless governing equations for unsteady, two-dimensional flow is red...

RESUMO Neste estudo se investigou as formas de enfrentamento do estresse e a presença dos sintomas depressivos em 100 indivíduos portadores de retocolite ulcerativa idiopática (RCUI), usuários do Ambulatório de Doenças Inflamatórias do HCFMUSP, que foram comparados com 100 indivíduos acompanhantes de pacientes de outra unidade da mesma instituição, isentos da doença. A metodologia consistiu de ...

Abstract We consider the two-dimensional shrinking target problem in beta dynamical systems (for general $\beta>1$ ) with errors of approximation. Let $f, g$ be two positive continuous functions. For any $x_0,y_0\in [0,1]$ , define set $$ \begin{align*}E(T_\beta, f,g):=\left\{(x,y)\in [0,1]^2: \begin{array}{@{}ll@{}} \lvert T_{\beta}^{n}x-x_{0}\rvert <e^{-S_nf(x)}\\[1ex] T_{\beta}^{n}y-y_...

Pregnancy-associated breast cancer is the most common malignancy during pregnancy with an expected rise in incidence. The belief in the need for termination of pregnancy and that chemotherapy is contra-indicated during pregnancy is challenged by recent evidence. Patients can consider breast-conserving surgery and sentinel lymph node biopsy with acceptably low fetal risk from radiation exposure....

To assess the safety of combined intervention in acute myocardial infarction, a pilot study of thrombolysis and beta-adrenergic blockade was performed. Twenty-five subjects were randomized to therapy with intravenous (IV) metoprolol and IV streptokinase (group 1) or to IV metoprolol (group 2) alone. Two-dimensional echocardiography was performed before intervention and five days later. The mean...

Objective: to demonstrate the effectiveness of combination of radial extracorporeal shock wave therapy and muscle energy technique on pain, range of motion, and neck function of the individuals with active trigger points of upper trapezius muscle. Method: Fifty-four (54) participants with active TrPs of upper trapezius muscle were participated and randomly divided into three groups. Group A (...