Background: Respiratory distress syndrome (RDS) is a medical emergency in infants resulting from a lack of or deficiency in surfactant, and leads to pulmonary failure. Surfactant and mechanical ventilation are among the primary treatments for helping infants with respiration. Some sedative drugs, such as benzodiazepines and opioids, are used to reduce stress and restlessness in...

The aim was to study the efficacy of rescue High Frequency Oscillatory Ventilation (HFOV) in improving the oxygenation and ventilation in neonates with acute respiratory failure after failing Conventional Mechanical Ventilation (CMV). Primary outcome was short term oxygenation, lung recruitment, and ventilation and secondary outcome studied was survival. 675 babies were ventilated and 97 of the...

Neonatal respiratory failure consists of several different disease entities, with different pathophysiologies. During the past 30 years technological advances have drastically altered both the diagnostic and therapeutic approaches to newborns requiring mechanical assistance. Treatments have become both patient- and disease-specific. The clinician has numerous choices among the noninvasive and i...

Introduction The process of lung inflation during mechanical ventilation is characterized by phenomena of alveolar recruitment and distension but regional interaction and temporal sequence are not known for the core areas of the lung. The only information available are referred to subpleural alveoli, studied by microscopy. Relevance of this issue derives from the notion that 1) radiologic studi...

22 The inflammatory response is a primary mechanism in the pathogenesis of ventilator-induced 23 lung injury. Autophagy is an essential, homeostatic process by which cells break down their own 24 components. We explored the role of autophagy in the mechanisms of mechanical ventilation25 induced lung inflammatory injury. Mice were subjected to low (7 ml/kg) or high (28 ml/kg) tidal 26 volume ven...

Positive-pressure mechanical ventilation supports gas exchange in patients with respiratory failure but is also responsible for significant lung injury. In this study, we have developed an in vitro model in which isolated lung cells can be submitted to a prolonged cyclic pressure-stretching strain resembling that of conventional mechanical ventilation. In this model, cells cultured on a Silasti...

BACKGROUND Morbid obesity predisposes patients to lung collapse and hypoxemia during induction of anesthesia. The aim of this prospective study was to determine whether noninvasive positive pressure ventilation (NPPV) improves arterial oxygenation and end-expiratory lung volume (EELV) compared with conventional preoxygenation, and whether NPPV followed by early recruitment maneuver (RM) after e...

Twenty-five newborn infants with severe respiratory failure responding poorly to conventional mechanical ventilation were switched to high-frequency positive-pressure ventilation (HFPPV) at 90 to 180 cycle/min (mean 158), an estimated tidal volume less than or equal to 3 ml/kg body weight, an inspiratory time of 0.1 sec, and a PEEP of 3 to 17 cm H2O. In all infants, HFPPV increased PaO2 (mean 6...