Conventional genome-wide association studies (GWAS) have been proven to be a successful strategy for identifying genetic variants associated with complex human traits. However, there is still a large heritability gap between GWAS and transitional family studies. The "missing heritability" has been suggested to be due to lack of studies focused on epistasis, also called gene-gene interactions, b...

Anomalies persist in the foundations of ridge regression as set forth in Hoerl and Kennard (1970) and subsequently. Conventional ridge estimators and their properties do not follow on constraining lengths of solution vectors using LaGrange’s method, as claimed. Estimators so constrained have singular distributions; the proposed solutions are not necessarily minimizing; and heretofore undiscover...

Anomalies persist in the foundations of ridge regression as set forth in Hoerl and Kennard (1970) and subsequently. Conventional ridge estimators and their properties do not follow on constraining lengths of solution vectors using LaGrange’s method, as claimed. Estimators so constrained have singular distributions; the proposed solutions are not necessarily minimizing; and heretofore undiscover...