Background: Epilepsy is the 2nd greatest prevalent brain ailment after stroke, and a huge load on health system. Currently available antiepileptic drugs are associated with a lot of adverse effects and exhibit erratic pharmacological effects; hence it is crucial to explore newer anticonvulsant medications having better side effect profile and enhanced pharmacological effects because of the leng...

Benign convulsions associated with gastroenteritis are now recognized as a clinical entity, characterized by an acute cluster of afebrile seizures during an episode of mild diarrhoea with excellent prognosis. We observed 30 children who each experienced at least two seizures associated with mild gastroenteritis. The inclusion criteria were: afebrile seizures during gastroenteritis, dehydration ...

The frequent co-existence of depression in epileptic patients raises the issue of simultaneous use of antidepressants along with anti-epileptic drugs in management of such cases. However, it is necessary to evaluate the safety of these antiepileptic/antidepressant drug combinations. The present study investigates the effect of either antidepressant; escitalopram (selective serotonin reuptake in...

Taxus wallichiana Zucc. (Himalayan Yew) is often used in northern areas of Pakistan for the treatment of pyrexia, acute pains and epilepsy. We have investigated certain pharmacological activities of the methanol leaf extract against convulsion, nociception and pyrexia induced in rodents. The aim was to justify and explore its folk uses in these pathological conditions, on scientific basis. The ...

Incomplete case finding is a problem in epidemiological studies of epilepsy. We tried to optimize case ascertainment by combining information from individual interviews and medical records. During 2 years, 1838 inhabitants of Vågå, Norway, aged 18-65 (88.6% of the target population) were interviewed as part of an epidemiological study of headache. Individuals with learning disability, mental di...

Various morphological parts of Persea americana Mill (Lauraceae) (avocado) are widely used in African traditional medicines for the treatment, management and/or control of a variety of human ailments, including childhood convulsions and epilepsy. This study examined the anticonvulsant effect of the plant's leaf aqueous extract (PAE, 50-800 mg/kg i.p.) against pentylenetetrazole (PTZ)-, picrotox...

INTRODUCTION Epilepsy is a common central nervous system (CNS) disorder characterized by seizures resulting from episodic neuronal discharges. The incidence of toxicity and refractoriness has compromised the clinical efficacy of the drugs currently used for the treatment of convulsions. Thus, there is a need to search for new medicines from plant origin that are readily available and safer for ...

Introduction: Extradural hematoma is a common pathology in our department. The natural history of small-volume usually towards resorption. In rare cases, the calcifies and compresses brain. We report an extradural 15-year-old boy who had road traffic accident on February 2011. brain CT-scan performed following day revealed small right frontal hematoma. During hospitalization, he fever 40 degree...

In the course of work already reported (1) (2) on the relationship of water balance to the occurrence of convulsions in severely epileptic children, it was found that seizures, after having been brought under control by the production of a deficit in the body water, could be made to recur practically at will by the rapid reestablishment of a positive water balance with pituitary antidiuresis. T...

Background: Carum carvi L. (caraway), known as black zeera in Iran, has been indicated for the treatment of epilepsy in Iranian folk medicine. This study evaluated whether the aqueous extract and essential oil of caraway seeds have anticonvulsant effects in mice.Methods: The anticonvulsant effects of the aqueous extract (200, 400, 800, 1600, and 3200 mg/kg, i.p.) and essential oil (25, 50, 100,...