HCTHematopoietic cell transplantation (HCT) refers to a procedure in which hematopoietic stem cells are infused to restore bone marrow function in cancer patients who receive bone-marrowtoxic doses of cytotoxic drugs, with or without whole-body radiation therapy. Hematopoietic stem cells may be obtained from the transplant recipient (autologous HCT) or from a donor (allogeneic HCT). They can be...

We analyzed the factors and outcome of patients with disseminated adenovirus infection (dAdV) after allogeneic hematopoeitic stem cell transplantation (HSCT). Thirty patients with dAdV were identified among 620 allogeneic HSCT recipients. Primary diseases were leukemia (n=17), Fanconi anemia (n=12) or others (n=1). Source of stem cells was unrelated in 28 and related in 2 patients. The graft co...

neurotrauma is one of the main medical problems that affect considerable number of population especially young persons in all countries. neurotrauma not only is a serious threat for life but also creates various disabilities and consequently imposes large costs to society. following central nervous system (cns) injury, tissue damage occurs via primary and secondary mechanisms. despite many atte...

Improving umbilical cord blood stem cell engraftment by ex vivo expansion of hematopoietic stem and progenitor cells 1. Impaired thymopoiesis is associated with severe infections after double umbilical cord blood transplantation (dUCBT). Monitoring of sjTREC + T cell recovery in dUCBT patients should therefore be considered to identify patients in need for intensified support. (this thesis) 2. ...

This review of the immunogenetics of cord blood transplantation attempts to highlight the connections between classical studies and conclusions of the tissue transplantation field as a scholarly endeavor, exemplified by the work of Professor Hoecker, with the motivations and some recent and key results of clinical cord blood transplantation. The authors review the evolution of understanding of ...

Umbilical cord blood hematopoietic stem cells (UCB HSCs) transplantation has attracted the attention of many researchers due to low probability GVHD and HLA mismatching; however, use this resource for adults been limited inadequate number CD34+ HSC from any individual donor. Recent reports indicate that circular RNAs (circRNAs) are involved in cell properties. In study, expression several candi...

the stem cells can be considered as the miracle of creation, because, they are a major reservoir of the bioactive factors, molecules and cells. these reservoir cells play a major role in development and growth of the tissues and organs. regardless of the differences in differentiation capacity of embryonic and adult stem cells, both the cells are rich sources of stem cells with therapeutic appl...