The hepatitis C virus (HCV) genome possesses an open reading frame (ORF) overlapping the core gene at +1 nucleotide (core+1 ORF). Initial in vitro studies suggested that the core+1 ORF is translated by a ribosomal -2/+1 frameshift mechanism during elongation of the viral polyprotein. Recent studies, however, based on transfection of mammalian cells with reporter constructs have shown that trans...

in this study calf thymus chromatin was fractionated into active (s1 and s2) and inactive (p 2) chromatin. then the interaction of an anthracyc1ine antibiotic, adriamycin, with these fractions was investigated employing absorption and difference uv nis spectroscopy and sds and agarose gel electrophoreses. the results suggest that the binding of adriamycin to the s 1 fraction is slight but s2 an...

Compressional seismic wave reflected off the Earth's inner core boundary (ICB) from earthquakes occurring in the Banda Sea and recorded at the Hi-net stations in Japan exhibits significant variations in travel time (from -2 to 2.5 s) and amplitude (with a factor of more than 4) across the seismic array. Such variations indicate that Earth's ICB is irregular, with a combination of at least two s...

Auto-inhibition is a common transcriptional control mechanism that is well characterized in the regulatory transcription factor Ets-1. Autoinhibition of Ets-1 DNA binding works through an inhibitory module that exists in two conformations. DNA binding requires a change in the inhibitory module from the packed to disrupted conformation. This structural switch provides a mechanism to tightly regu...

The biological role of the protein encoded by the alternative open reading frame (core+1/ARF) of the Hepatitis C virus (HCV) genome remains elusive, as does the significance of the production of corresponding antibodies in HCV infection. We investigated the prevalence of anti-core and anti-core+1/ARFP antibodies in HCV-positive blood donors from Cambodia, using peptide and recombinant protein-b...

conclusions the canola oilseeds could provide a useful expression system to produce hcv core protein as a vaccine candidate. results western blot analysis using anti-his antibody confirmed the presence of a 15 kda protein in the seeds of t1 transgenic lines. the amount of antigenic protein accumulated in the seeds of these transgenic lines was up to 0.05% of the total soluble protein (tsp). mat...

purpose: this research aimed to study the effect of 8 weeks core stability training on static balance of the children with down syndrome. methods: a total of 16 children with down syndrome from rehabilitation center of noor abad city were selected and randomly divided into 2 groups of control (n=8) and experimental (n=8). at the pretest and posttest, subjects’ static balances were evaluated by ...

this paper is a report on the synthesis of the fe3o4@ag core-shell with high saturation magnetization of magnetite nanoparticles as the core, by using polyol route and silver shell by chemical reduction. x-ray diffraction (xrd) and fourier transform infrared spectroscopy analyses confirmed that the particles so produced were monophase. the magnetic properties of the product were investigated by...

introduction: websites of academic journals have an important role in communicating and providing services to researchers. the present study aimed to determine the number of incoming links of iranian journal of medical sciences websites. besides, it aimed to determine the rate of visibility of core websites based on these findings. methods: this descriptive study was performed using webometrics...