.............................................................................................................................. iii Yunus Annayev: Characterization of a new circadian clock gene Gm129 ................................ iii ACKNOWLEDGEMENTS ........................................................................................................ v TABLE OF CONTENTS ......................

INTRODUCTION Metastases remain the primary cause of cancer-related death. The acquisition of invasive tumour cell behaviour is thought to be a cornerstone of the metastatic cascade. Therefore, gene signatures related to invasiveness could aid in stratifying patients according to their prognostic profile. In the present study we aimed at identifying an invasiveness gene signature and investigate...

The availability of systematic drug response registries for hundreds cell lines, coupled with the comprehensive profiling their genomes/transcriptomes enabled development computational methods that investigate molecular basis responsiveness. Herein, we propose an automated, multi-omics systems pharmacology method identifies genomic markers anti-cancer response. Given a cancer type and therapeut...

OBJECTIVE To determine an association between transmission of hepatitis B virus and secretor and non-secretor status of salivary blood group antigens. STUDY DESIGN Cross-sectional, analytical study. PLACE AND DURATION OF STUDY The Department of Physiology and Division of Hepatology, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia, ...

BACKGROUND The purpose of this study was to explore molecular epidemiology of HCV genotype 3a in Peshawar based on sequencing and phylogenetic analysis of Core region of HCV genome. METHODS Chronically infected Hepatitis C virus infected patients enrolled under the Prime Minister Hepatitis C control program at three Tertiary care units of Peshawar [Khyber Teaching Hospital Peshawar, Lady Read...

Red gene is the spiritual core and “genetic map” of red culture it political mission responsibility colleges to implement “educating people with moral values”. The teaching objectives, contents methods translation courses integrate education gene, which conducive implantation in course. It carried out by introducing history translation, integrating local “Internet+ Culture Resource Project”. hi...

Abstract Evidence suggests that shared pathophysiological mechanisms in neuropsychiatric disorders (NPDs) may contribute to risk and resilience. We used single-gene network-level transcriptomic approaches investigate disorder-specific processes underlying posttraumatic stress disorder (PTSD), Parkinson’s disease (PD) schizophrenia a South African sample. RNA-seq was performed on blood obtained ...

waaP is present in the lipopolysaccharide (LPS) core gene clusters of a wide range of gram-negative bacteria, and is an essential gene in Pseudomonas aeruginosa. The WaaP protein is a sugar kinase that adds phosphate to heptose I in the core oligosaccharide. This study describes the standardization and utility of a chemiluminescence-based enzyme-linked immunosorbent assay for the detection of W...

Gene-set analysis aims to identify differentially expressed gene sets (pathways) by a phenotype in DNA microarray studies. We review here important methodological aspects of gene-set analysis and illustrate them with varying performance of several methods proposed in the literature. We emphasize the importance of distinguishing between 'self-contained' versus 'competitive' methods, following Go...