Previous studies showed that HIV-1 reverse transcription occurs during or before uncoating, linking mechanistically reverse transcription with uncoating. Here we show that inhibition of reverse transcriptase (RT) during HIV-1 infection by pharmacologic or genetic means increased the stability of the HIV-1 core during infection. Interestingly, HIV-1 particles with increased core stability were r...

This paper studies the Nash stability in hedonic coalition formation games. We address the following issue: for a general problem formulation, is there any utility allocation method ensuring a Nash-stable partition? We propose the definition of the Nash-stable core and we analyze the conditions for having a non-empty Nash-stable core. More precisely, we prove that using relaxed efficiency in ut...

Virions of human immunodeficiency virus type 1 (HIV-1) and other lentiviruses contain conical cores consisting of a protein shell composed of the viral capsid protein (CA) surrounding an internal viral ribonucleoprotein complex. Although genetic studies have implicated CA in both early and late stages of the virus replication cycle, the mechanism of core disassembly following penetration of tar...

Studies of the overall structure of vocabulary and its dynamics became possible due to creation of diachronic text corpora, especially Google Books Ngram. This article discusses the question of core change rate and the degree to which the core words cover the texts. Different periods of the last three centuries and six main European languages presented in Google Books Ngram are compared. The ma...

Background: Low Back Pain (LBP) is a health related problem than affects 80% of the population within the age limit of 15 to 45 years. The primary treatment used for patients with LBP includes muscle strengthening along with thermotherapeutic modalities. Thus the purpose of the study is to see the efficacy of EMG biofeedback assisted core stability exercises versus core stability exercises alon...

the manner of spray the fuel has an important effect on stability and convenient mixture of fuel and oxidizer. swirl injectors because of formation of uniform spray cone and proper distribution of the fuel have been used in many rocket engines at aerospace industries. formation and development of air core in the interior stream of swirl injectors and simulation of them is complicated. double ba...

we have studied the effect of hypothetical cosmions on the core stability of main sequence stars (of populations i and ii). cosmions, with a mass of 4-10 gev/c2 and a scattering cross section with nucleons of approximately 10-36 cm2 could prevail in transporting heat in the stellar cores. raby [17] showed the existence of a local thermal instability caused by the presence of cosmions in the sol...

The core domain of the tumour suppressor p53 is of inherently low thermodynamic stability and also low kinetic stability, which leads to rapid irreversible denaturation. Some oncogenic mutations of p53 act by just making the core domain thermosensitive, and so it is the target of novel anti-cancer drugs that bind to and stabilise the protein. Increasing the stability of the unstable core domain...

The stability of the HIV-1 core in the cytoplasm is crucial for productive HIV-1 infection. Mutations that stabilize or destabilize the core showed defects on HIV-1 reverse transcription and infection. We developed a novel and simple assay to measure the stability of in vitro-assembled HIV-1 CA-NC complexes. The assay allowed us to demonstrate that cytosolic extracts strongly stabilize the HIV-...