Reports of increased corneal thickness and altered endothelial morphology suggest that there is abnormal corneal hydration control in diabetic patients. To study the possible influence of hyperglycemia on corneal hydration control, experiments were done on normal and alloxan-induced diabetic rabbits to assess: (1) stromal dry weight, hydration, and swelling pressure; (2) corneal thickness and c...

The cornea is the main refracting surface of the eye1,2,3, comprised of five layers with a sixth corneal layer positioned between the stroma and Descemet’s membrane being proposed.4 The cornea serves many functions which include acting as a convex refracting surface, serving as a barrier against foreign bodies and aiding in stabilisation of the tear film.2 The average central corneal thickness,...

OBJECTIVE To evaluate the efficacy of using a porcine small intestinal submucosa (SIS) graft covered by a conjunctival flap for the surgical repair of full-thickness corneal wounds in dogs, cats and horses. PROCEDURE All records dating from August 1999 to February 2003 from Purdue University Veterinary Teaching Hospital of patients that had undergone ophthalmic surgical procedures and receive...

PURPOSE To introduce a new model describing human in vivo corneal deswelling after hypoxic contact lens wear, based on a damped harmonic oscillator, which can describe an overshoot in corneal deswelling, to compare this new model with the currently used exponential model, and also to test whether a diurnal variation in baseline corneal thickness exists that would have to be taken into considera...

PURPOSE To identify factors that can lead to corneal ectasia after laser in situ keratomileusis (LASIK). SETTING University refractive surgery center. METHODS In this retrospective study, the charts of all patients (2873 eyes) who had LASIK between May 1995 and November 1999 were reviewed. Fourteen patients (19 eyes, 0.66%) developed post-LASIK ectasia. The mean follow-up was 16.32 months (...

A thick cornea is a constant ocular finding in the mesodermal dysmorphodystrophy (Weill-Marchesani Syndrome). In this study we investigated with confocal microscopy, the corneal structure in vivo in the patient affected by Weill-Marchesani Syndrome (WMS) in an attempt to explain the thickness increment. The corneal study showed in both eyes a highly increased central thickness with normal topog...

A candidate for refractive surgery presented with classic (type I) Ehlers-Danlos syndrome (EDS). Clinical examination revealed blue sclera, limbus-to-limbus corneal thinning, myopia, and astigmatism. Orbscan (Bausch & Lomb) pachymetry mapping provided a striking demonstration of the limbus-to-limbus thinning with a central corneal thickness of 360 microm in the right eye and 383 microm in the l...

PURPOSE To quantify keratocyte density according to stromal region and subject age and to measure the thickness of the normal human cornea and its layers in vivo. METHODS Seventy normal corneas of 70 subjects were examined by confocal microscopy (contact lens wearers were excluded). Ages of subjects ranged from 12 to 80 years, with 10 subjects per decade. Images were recorded by continuously ...

PURPOSE To determine whether optical coherence tomography (OCT) epithelial mapping can improve the detection of form fruste keratoconus. SETTING French National Eye Hospital, Paris 6 Pierre & Marie Curie University, Paris, France. DESIGN Retrospective comparative study. METHODS Eyes with normal corneas, form fruste keratoconus, moderate keratoconus, or severe keratoconus were assessed usi...