Microbial keratitis is a major cause of corneal opacity and loss of vision worldwide. Ulcerative microbial keratitis remains a leading cause of blindness worldwide. The most common causative organisms are bacteria, although fungi and protists can also cause keratitis. Bacterial keratitis is potentially more devastating ocular infection. The most common bacteria associated with corneal ulcer are...

A29 year old woman, who was an intermittent contact lens wearer, is referred from her local ophthalmologist with a diagnosis of microbial keratitis. There is a large central corneal ulcer with stromal white cell recruitment and low grade anterior chamber (AC) activity. The patient has no other eye problems and is in good health. Would you perform a corneal scraping? Which antibiotics would you ...

An 11-year-old Brown Swiss cow was referred to the Farm Animal Department of the Veterinary Teaching Hospital in Zurich, Switzerland, because of lateral recumbency due to puerperal hemolytic anemia. The animal had developed enophthalmos due to dehydration at the time of presentation. Two days after hospitalization, the cow showed blepharospasm and epiphora of the right eye. Ophthalmic examinati...

The epidemiology of microbial keratitis has been investigated in several studies by analysis of organisms cultured from corneal scrapes. However, a comparison of the frequency of different organisms causing keratitis in different parts of the world is lacking. The authors present a review incorporating an analysis of data from studies worldwide. The data provide a comparison of the frequency of...

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We present the case of a female patient, 30 years old, who developed a perforated corneal ulcer at which we made an amniotic membrane graft as a temporary solution in order to save the eye

CASE REPORT We present the case of a 29 year-old man who came to the Emergency Department due to pain in the right eye. There was demonstrated a complete corneal de-epithelialisation. There was no clinical improvement after appropriate treatment, which was complicated by migraine and vomiting. The computerized tomography (CT) scan showed images suggestive of cerebral toxoplasmosis. After the co...

Purpose The purpose of this study was to determine the safety of topical ocular administration of a cross-linked, modified hyaluronic acid (xCMHA-S) hydrogel, and its effectiveness in accelerating repair and closure of acute and nonhealing corneal ulcers in companion animals as a veterinary treatment and its utility as a model for therapy in human corneal ulceration. Methods Two concentration...

To the Editor: The case series study by Ehlers et al,1 which appeared in the September 2009 issue of the Journal of Refractive Surgery, presented the results of ribofl avin-ultraviolet A (UVA) treatment in the management of edema and nonhealing ulcers of the cornea. Both the effi cacy and safety of this method in the treatment of persisting nonhealing corneal ulcers were remarkable; 6 of 14 eye...