Dry eye syndrome is caused by a reduction in the volume or quality of tears. Here, we show that pituitary adenylate cyclase-activating polypeptide (PACAP)-null mice develop dry eye-like symptoms such as corneal keratinization and tear reduction. PACAP immunoreactivity is co-localized with a neuronal marker, and PACAP receptor (PAC1-R) immunoreactivity is observed in mouse infraorbital lacrimal ...

The present study investigated the effects of microinjections of acetylcholine (a cholinergic agonist), physostigmine (a cholinesterase inhibitor), atropine (an antagonist of muscarinic cholinergic receptors) and hexamethonium (an antagonist of nicotinic cholinergic receptors) into the parafascicular nucleus of thalamus on the acute corneal nociception in rats. Acute corneal nociception was ind...

purpose: to evaluate the effect of topical phenytoin 1 % on corneal epithelial defects healing in a rabbit model. methods: one eye of 20 albino rabbits in the animal house of al-zahra ophthalmology hospital was studied. a single corneal epithelial defect was created. the rabbits were randomly assigned into two groups (ten animals in each group). after creating a chemical burn in rabbits, one gr...

PURPOSE To evaluate the clinical results of epitheliumoff corneal cross-linking (CXL) during a 7-year follow-up. METHODS This retrospective, non-randomized, single-center interventional study enrolled 34 consecutive eyes of 24 patients with progressive keratoconus undergoing CXL surgery with epithelium removal. Visual, refractive, corneal topographic, pachymetric, and anterior segment changes...

Dry eye disease (DED) is a multifactorial disorder affecting the composition and volume of tears. DED causes ocular surface dryness, cooling, and hyperosmolality, leading ultimately to corneal epithelium damage and reduced visual performance. Ocular discomfort is the main clinical symptom in DED. However, the peripheral neural source of such unpleasant sensations is still unclear. We analyzed i...

Optical coherence tomography (OCT) can monitor human donor corneas non-invasively during the de-swelling process following storage for corneal transplantation, but currently only resultant thickness as a function of time is extracted. To visualize and quantify the mechanism of de-swelling, we present a method exploiting the nanometer sensitivity of the Fourier phase in OCT data to image deforma...

Over the past two decades, computational fluid dynamics and particularly the finite volume method have been increasingly used to predict the performance of wind turbines within their environment. Increases in available computational power has led to the application of RANS-based models to more and more complex flow problems and permitted the use of LES-based models where previously not possible...

This paper, which is largely the fruit of an invited talk on the topic at the latest International Conference on Coastal Engineering, describes the state of the art of modelling by means of Boussinesq-type models (BTMs). Motivations for using BTMs as well as their fundamentals are illustrated, with special attention to the interplay between the physics to be described, the chosen model equation...

In this study, some important variables in the bioleaching, such as ferric and zinc ions concentration in the liquid phase and velocity field around a single particle were simulated. Volume of fluid (VOF) method was used to predict the mentioned fields in a 3D geometry. Results show that VOF is a successful approach for prediction of velocity and concentration fields. The computational model ha...

COMMUNITY EYE HEALTH JOURNAL | VOLUME 30 | NUMBER 100 | 2017 Nearly a third of the very first issue of the Community Eye Health Journal was about blinding eye diseases in children. One article described an Indian study about improving mothers’ knowledge so that they could prevent eye conditions in their children. The other article also focused on the major causes of corneal scarring in children...