PURPOSE To evaluate the sensitivity, specificity, and test accuracy of corneal biomechanical metrics and anterior segment data in differentiating keratoconus from healthy corneas. METHODS Comparative case series. Patients with and without keratoconus (gender and age-matched) were submitted for complete eye examinations including corneal hysteresis (CH) and corneal resistance factor (CRF) as m...

Purpose: To evaluate the corneal asphericity, volume, thickness and keratometry and the correlation among these variables in keratoconus patients. Materials and methods: A total of 1,071 eyes of 810 patients diagnosed with keratoconus were evaluated with a Pentacam (Oculus Optikgerate GmbH). Five groups were established according to the mean keratometry readings: Very mild [K < 44.0 diopters (D...

Aim: The primary aim of this study was to find if there is any correlation between the corneal radius of curvature and its eccentricity. Method: 45 subjects participated in this study, 24 emmetropes, 18 myopes and three hyperopes. All subjects were free of ocular abnormalities and had no media opacities. All the subjects had normal ocular health and good visual acuity of 1.0 or better for both ...

Although subclinical involvement of sensory neurons in amyotrophic lateral sclerosis (ALS) has been previously demonstrated, corneal small fiber sensory neuropathy has not been reported to-date. We examined a group of sporadic ALS patients with corneal confocal microscopy, a recently developed imaging technique allowing in vivo observation of corneal small sensory fibers. Corneal confocal micro...

AIMS The tonographic effect is a phenomenon of intraocular pressure (IOP) reduction following repeated tonometry. This study examines whether the tonographic effect occurs following IOP measurement performed with Ocular Response Analyzer (ORA). METHODS Both eyes of 31 glaucoma patients and 35 healthy controls underwent nine IOP-measurements performed with GAT and ORA. The number of GAT and OR...

PURPOSE In this study, the beneficial effects of the oral administration of ethanol extract of Diospyros kaki (EEDK) were tested on a mouse dry eye model induced by benzalkonium chloride (BAC). METHODS A solution of 0.2% BAC was administered topically to mouse eyes for 14 days, twice daily, to induce dry eye. Various concentrations of EEDK were administrated daily by oral gavage for 14 days a...

Purpose To evaluate transient corneal tissue healing and biomechanical changes between laser in situ keratomileusis (LASIK) and small incision lenticule extraction (SMILE) eyes. Methods In each patient, one eye underwent LASIK and the other underwent SMILE. Optical coherence tomography (OCT) and dynamic Scheimpflug imaging (Corvis-ST) was used to assess tissue healing and biomechanics, respec...

T cell mediated immune responses against the cornea specific protein BCP 54 have been observed in patients with uveitis, Fuchs' heterochromic cyclitis, and corneal disease. The pathophysiological role of this anti-BCP 54 response in corneal disease is not known. In order to ascertain whether the presence of such an immune response is related to the corneal disease itself or related to genetic i...

PURPOSE To evaluate and compare the toxic effects of eyedrops containing a fixed combination of 2.0% dorzolamide and 0.5% maleate timolol with or without preservatives on rabbit corneal endothelium. METHODS This study was performed with 22 eyes of New Zealand white rabbits. Dorzolamide/timolol eyedrops with preservative (Cosopt group) or without preservative (Cosopt-S group) were diluted with...

Corneal transparency relies on the precise arrangement and orientation of collagen fibrils, made mostly Type I V fibrils proteoglycans (PGs). PGs are essential for correct fibrillogenesis maintaining corneal homeostasis. We investigated spatial temporal distribution glycosaminoglycans (GAGs) after a chemical injury. The composition chondroitin sulfate (CS)/dermatan (DS) heparan (HS) were charac...