A polipoprotein D is expressed in many tissues after injury , such as reperfusion injury after myocardial in-farction. Antioxidant activity of apolipoprotein D appears to confer cardioprotective properties after myocardial in-farction in a mouse model of severe rapidly progressing coronary atherosclerosis and in a mouse model of isch-emia/reperfusion injury. Mice with homozygous-null mutations ...

Background. To test the hypothesis that the heat shock response is associated with myocardial salvage, the heat stress protein (HSP) content of cardiac tissue was increased by either ischemic or thermal stress. Methods and Results. Rabbits were divided into four groups. Ischemic pretreatment (n= 15) comprised four 5-minute episodes of coronary ligation separated by 10 minutes of reperfusion. Th...

OBJECTIVES Atherosclerotic lesions of the coronary arteries are the pathological basis for myocardial infarction and ischemic cardiomyopathy. Progression of heart failure after myocardial infarction is associated with cardiac remodeling, which has been studied by means of coronary ligation in mice. However, this ligation model requires excellent techniques. Recently, a new murine model, HypoE m...

Coronary artery aneurysms are noted in 0.15% to 4.9% of patients undergoing coronary angiography. Atherosclerosis accounts for 50% of coronary aneurysms in adults. We report a 64-year-old female with a huge right coronary artery aneurysm with fistula connecting the aneurysm with the pulmonary artery and a fistula connecting the proximal left anterior descending artery with the pulmonary artery....

We report a case of a 57-year-old man with typical angina due to a coronary artery-to-pulmonary artery fistula, which was evident on transthoracic and transesophageal echocardiography with color Doppler flow mapping. The diagnosis was confirmed by coronary angiography. The patient underwent surgical ligation of the fistula. However, repeated transesophageal echocardiography and coronary angiogr...

The changes in the coronary circulation, which are precipitated by the acute occlusion of the coronary sinus, have been investigated. In normal animals, retrograde blood emerging from the peripheral segment of a ligated and transected circumflex coronary artery is small in quantity, and arterial in nature, signifying an insignificant interarterial collateral flow. After the coronary sinus is ar...

Anomalous origin of the left coronary artery from the pulmonary artery is a rare, almost universally fatal form of congenital heart disease. A case was diagnosed in a 19 year old woman who had exercise induced syncope and ST segment displacement during exercise stress testing. The anomaly was successfully treated with ligation of the anomalous left coronary artery combined with saphenous vein g...

INTRODUCTION To date, most animal studies of myocardial ischemia have used open-chest models with direct surgical coronary artery ligation. We aimed to develop a novel, percutaneous, minimally-invasive, closed-chest model of experimental myocardial infarction (EMI) in the New Zealand White rabbit and compare it with the standard open-chest surgical model in order to minimize local and systemic ...

Anomalous origin of the right coronary artery originating from the pulmonary trunk (ARCAPA) is a rare congenital coronary anomaly with an estimated prevalence of 0.002%. Most patients are asymptomatic and the anomaly is detected incidentally during evaluation for other problems. Occasionally, ARCAPA may lead to myocardial ischemia and/or sudden cardiac arrest. We present a case of a 55-year-old...