Four subtypes of frontotemporal lobar degeneration with TDP-43 immunoreactive inclusions have been described (types A-D). Of these four subtypes, motor neuron disease is more commonly associated with type B pathology, but has also been reported with type A pathology. We have noted, however, the unusual occurrence of cases of type C pathology having corticospinal tract degeneration. We aimed to ...

The corticospinal tract, a major neural tract in the human brain for motor function, is concerned mainly with movement of the distal extremities. Preservation or recovery of the corticospinal tract is essential for good recovery of impaired motor function in patients with brain injury. Therefore, thorough and precise knowledge of the corticospinal tract is necessary for successful brain rehabil...

OBJECTIVE To investigate the consistency of diffusion tensor tractography of the corticospinal tract on motor function. CLINICAL PRESENTATIONS AND INTERVENTION: Three patients with brain tumor were admitted to our hospital with impaired motor function. Diffusion tensor imaging (DTI) and tractography were performed in these patients to assess their affected corticospinal tract. The corticospinal...

Joubert syndrome (JS) is a rare genetic disorder characterized by a congenital malformation of the hindbrain, and accompanied by axonal decussation abnormalities affecting the corticospinal tract and the superior cerebellar peduncles. To the best of our knowledge, there are no reports of normal pyramidal decussation in JS. Here, we describe the case of an 18-year-old boy presenting midline-cros...

The corticospinal system is the principal motor system for controlling movements that require the greatest skill and flexibility. It is the last motor system to develop. The pattern of termination of corticospinal axons, as they grow into the spinal gray matter, bears little resemblance to the pattern later in development and in maturity. Refinement of corticospinal terminations occurs during a...

There is a high degree of specificity in the efferent connections of the cerebral cortex. In the rodent neocortex, the characteristic band of corticospinal neurons within layer V is present at birth even though changes still occur in the areal distribution of these neurons. Disruption of neocortical development with ionizing radiation before, during, or after the production of neurons destined ...

PURPOSE To determine whether pontomedullary corticospinal tract involvement is a common and specific finding of adrenoleukodystrophy on MR images. METHODS MR images of 10 patients with biochemically proved adrenoleukodystrophy who were examined during the last 6 years were reviewed retrospectively to determine the frequency of corticospinal tract involvement in the medulla, pons, mesencephalo...

BACKGROUND AND PURPOSE Diffusion tensor imaging fiber tractography-assisted planning of deep brain stimulation is an emerging technology. We investigated its accuracy by using electrophysiology under clinical conditions. We hypothesized that a level of concordance between electrophysiology and DTI fiber tractography can be reached, comparable with published modeling approaches for deep brain st...

Adult rats were trained to use their forepaws to retrieve a piece of food. Destruction of the dorsal corticospinal tract on one side at the level of the first cervical segment abolished the use of the ipsilateral forepaw for retrieval for at least 6 months after operation. Where a variable amount of the corticospinal tract was spared, there was a proportionate persistence of retrieval. In lesio...