Objective(s): We previously conducted an in silico research on the interactions between the ribosome display-selected single chain variable fragment (scFv) and factor H binding protein (fHbp) of Neisseria meningitidis. We found that heavy chain variable (VH) fragment of this scFv had considerable affinity to fHbp. These results led us to evaluate the ability of this sm...

The Google Desktop Search is an indexing tool, currently in beta testing, designed to allow users fast, intuitive, searching for local files. The principle interface is provided through a local web server which supports an interface similar to Google.com’s normal web page. Indexing of local files occurs when the system is idle, and understands a number of common file types. A optional feature i...

We study how to keep the Internet search engines up-todate with the changes occurring at the various web servers in the Internet. Currently, web search engines poll the web servers on a per-URL basis for obtaining update information. We advocate an approach in which web servers themselves track the changes happening to their content files for propagating updates to search engines. We propose an...

A Content Distribution Network, or CDN, is a system to improve the delivery of content to the end users (or clients) in the Internet, in which popular content may be cached or replicated at a number of servers, placed closer to some of the client populations. The design of a CDN consists of defining: (a) which content should be replicated at each server (server content), (b) the number of serve...

Personalization of Web services requires a powerful preference model that smoothly and efficiently integrates with standard database query languages. We make the case for preferences as strict partial orders, supported in Preference SQL and Preference XPATH. Performance of Web services will crucially depend on various architectural design decisions. We pointed out that a central server architec...

We consider an optimization problem for a multiclass queueing model of a decentralized production-distribution system: A single server can produce a variety of products, and completed units pass through an infinite server delay node on their way to a warehouse inventory. Each product has its own warehouse, demand for each product is satisfied by its associated inventory, and unsatisfied demand ...

A group of web-server system can be deployed to support high request rate. The Domain Name System (DNS) servers act as a mediator between the client and web-servers. It dispatches the client request among the web-servers through the URL-name to IP-address mapping mechanism. In this paper, we propose a group of web-server system arranged in the multiple logical ring connection, in which the DNS ...

Today world's dependence on the Internet and the emerging of Web 2.0 applications is significantly increasing the requirement of web robots crawling the sites to support services and technologies. Regardless of the advantages of robots, they may occupy the bandwidth and reduce the performance of web servers. Despite a variety of researches, there is no accurate method for classifying huge data ...

The long-term success of the World Wide Web depends on fast response time. People use the Web to access information from remote sites, but do not like to wait long for their results. The rapid growth in the amount of information and the number of users has lead to difficulty in providing effective response time for the web users and this increased web latency; resulting in decreased web perform...

Growing business demands for new IT functionality (web sites, self-service portals, ecommerce, etc.) has led to a proliferation of hardware and software in the data center. Initially, though the cost benefi ts of x86 servers were (and still are) compelling, concerns around performance and reliability dictated a “one server, one service” implementation approach, where individual servers were lim...