BACKGROUND Osteoarthritis (OA) is a heterogeneous group of conditions with disturbed integrity of articular cartilage and changes in the underlying bone. The pathogenesis of OA is multifactorial and not just a disease of older people. Hydroxychloroquine (HCQ) is a disease-modifying anti-rheumatic drug (DMARD) typically used for the treatment of various rheumatic and dermatologic diseases. Three...

Nonsteroidal anti-inflammatory drugs are one of the most frequent causes of immediate drug-induced skin hypersensitivity reactions worldwide (1). While a proportion of patients show reactivity to single, specific drugs, many others are intolerant to multiple NSAIDs; about one half of multiple reactors suffer from chronic spontaneous urticaria, while in the remaining no underlying factor can be ...

INTRODUCTION Faecal blood loss has been measured using autologous erythrocytes labelled with radioactive chromium for several decades, using generally similar methods. We conducted a systematic review of studies employing this technology to determine the degree of blood loss associated with use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclo-oxygenase-2 selective inhibitors ...

their fi ndings on NSAID use and breast cancer risk? The answer lies in an appreciation of the likely mechanisms of NSAID-mediated breast cancer suppression. COX enzymes, the primary molecular targets of NSAIDs, synthesize prostaglandins (PGs) from arachidonic acid (13 , 14). COX-1 is normally expressed constitutively, whereas COX-2 is an early-response gene whose expression is increased in res...

BACKGROUND Recent clinical trials and observational studies have reported increased coronary events associated with non steroidal anti-inflammatory drugs (NSAIDs). There appeared to be a disproportionate increase in non-fatal versus fatal events, however, numbers of fatal events in individual studies were too small, and event rates too low, to be meaningful. OBJECTIVES We undertook a pooled a...

Padol and Hunt hypothesize [1] that plaque instability and myocardial infarction (MI) contribute to cardiovascular (CV) reactions from NSAIDs, which arise from augmentation of lymphocyte Th1-type activation. The widely accepted dogma is that CV reactions from traditional NSAIDs and coxibs are caused by an imbalance of cyclo-oxygenase (COX)-2 inhibition by these drugs leading to reduced producti...