Quantum dots (QDs) are luminescent semiconductor nanocrystals that are widely used as fluorescent probes in biomedical applications, including cellular imaging and tumor tracking. Cell-penetrating peptides (CPPs), also called protein transduction domains (PTDs), are short basic peptides that permeate cell membranes and are able to deliver a variety of macromolecule cargoes, such as DNAs, RNAs, ...

Abstract The advent of smart manufacturing and the exposure to a new generation technological enablers have revolutionized way process is carried out. Cyber-Physical Production Systems (CPPS) are introduced as main actors this shift. They characterized for having high levels communication, integration computational capabilities that led them certain level autonomy. Despite expectations vision C...

Modern society is living at a time of revolutionary changes in all areas human life. For example, the field industrial manufacturing has greatly influenced role beings during past 30 years. systems are phase transition, accordance with concept fourth revolution (Industry 4.0). A new paradigm based on principles Industry 4.0 presented by Smart Manufacturing Systems (SMS). basic building block SM...

Cell-penetrating peptides (CPPs) have been attracting attention as tools for intracellular delivery of membrane-impermeant functional molecules. Among the variety CPPs that developed, many are composed both natural and unnatural amino acids. We previously synthesized α,α-disubstituted α-amino acids (dAAs) containing a five-membered carbocyclic ring in its side chain revealed utility dAAs develo...

Abstract The Cyber—Physical Power System (CPPS) is one of the most critical infrastructure systems in a country because stable and secure power supply key foundation for national social development. In recent years, resilience has become major topic preventing mitigating risks caused by large-scale blackouts CPPSs. Accordingly, concept significance CPPS are at first explained from engineering p...

BACKGROUND Recent data showed that a six-domain UPOINT is a flexible and responsive new classification system that has the clinical applicability in CP/CPPS. However, the utility of UPOINT algorithm in men in China with CP/CPPS has not been comprehensively studied. For international validation and adoption, we evaluated this clinical phenotype system for a large cohort of Chinese CP/CPPS patien...

Brain network activity associated with altered motor control in individuals with chronic pain is not well understood. Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a debilitating condition in which previous studies have revealed altered resting pelvic floor muscle activity in men with CP/CPPS compared to healthy controls. We hypothesized that the brain networks controlling pelvi...

BACKGROUND Previously reported results of a prospective, randomized placebo-controlled study showed that the pollen extract (Cernilton) significantly improved total symptoms, pain, and quality of life in patients with inflammatory prostatitis/chronic pelvic pain syndrome (CP/CPPS) without severe side effects. A phytotherapeutic agent, Eviprostat, is reportedly effective in a rat model of nonbac...

Cell-penetrating peptides (CPPs) are a group of peptides, which have the ability to cross cell membrane bilayers. CPPs themselves can exert biological activity and can be formed endogenously. Fragmentary studies demonstrate their ability to enhance transport of different cargoes across the blood-brain barrier (BBB). However, comparative, quantitative data on the BBB permeability of different CP...

A growing number of natural and/or synthetic peptides with cell membrane penetrating capability have been identified and described in the past years. These molecules have been considered promising tools for delivering bioactive compounds into various cell types. Although the mechanism of uptake is still unclear, it is reasonable to assume that the relative contribute of each proposed mechanism ...