Cyber-physical systems (CPS) integrate computation with sensing, control, and physical systems and will enable development of next-generation services and smart infrastructure across many application domains. However, a significant impediment to the use of CPS in trusted and trustworthy systems is their vulnerability to security attacks. Some properties of CPS that exacerbate security concerns ...

The innate immune system plays a critical role in the defense of areas exposed to microorganisms. There is an increasing body of evidence indicating that antimicrobial peptides and proteins (APs) are one of the most important weapons of this system and that they make up the protective front for the respiratory tract. On the other hand, it is known that pathogenic organisms have developed counte...

Reversing tumor-associated immunosuppression seems necessary to stimulate effective therapeutic immunity against lethal epithelial tumors. Here, we show this goal can be addressed using cps, an avirulent, nonreplicating uracil auxotroph strain of the parasite Toxoplasma gondii (T. gondii), which preferentially invades immunosuppressive CD11cþ antigen-presenting cells in the ovarian carcinoma mi...

OBJECTIVE Newer non-benzodiazepines zolpidem and zopiclone ("Z-drugs") are often prescribed instead of benzodiazepine hypnotics, although there is no evidence of differences in effectiveness and safety. Aim was to compare perceptions on benefits and harms of benzodiazepines and Z-drugs between general practitioners (GPs) and community pharmacists (CPs). METHODS A questionnaire was mailed to a...

Immunization of healthy volunteers with chloroquine ChemoProphylaxis and Sporozoites (CPS-CQ) efficiently and reproducibly induces dose-dependent and long-lasting protection against homologous Plasmodium falciparum challenge. Here, we studied whether chloroquine can be replaced by mefloquine, which is the only other licensed anti-malarial chemoprophylactic drug that does not affect pre-erythroc...

The physical world will be saturated by networked devices with sensing and actuating capabilities. This trend will generate profound impacts on our way of monitoring and controlling the physical world, and meanwhile bring us towards a cyber-physical convergence era. Along this trend, a new type of systems, named Cyber-Physical Systems (CPS), is developed by taking into consideration the cyber a...

BACKGROUND Craniopharyngiomas (CPs) are benign, locally aggressive neoplasms that comprise approximately 10% of pediatric brain tumors. The role of surgical management for CPs is discussed in this review. METHODS A review of the goals and techniques associated with selected surgical approaches for the treatment of CPs in the pediatric population is provided. RESULTS CPs may be a cause of si...

Since nasopharyngeal carriage of pneumococcus precedes invasive pneumococcal disease, characteristics of carriage isolates could be incorrectly assumed to reflect those of invasive isolates. While most pneumococci express a capsular polysaccharide, nontypeable pneumococci are sometimes isolated. Carriage nontypeables tend to encode novel surface proteins in place of a capsular polysaccharide sy...

1. INTRODUCTION Multisensor image registration is necessary in many applications of remote sensing imagery, whose crucial problem is how to establish the correspondence between the features extracted from the reference and input images. Most existing methods only consider how to extract features, however, the quality of the features are ignored. In this paper, we combine scale invariant feature...

Studies estimate that domestic violence is present in at least one-third of the families involved in child protective services (CPS). Yet, until recently, CPS has not directly addressed domestic violence in its handling of child abuse and neglect cases. By the same token, domestic violence programs have historically emphasized services for battered women, with limited understanding of the child...