Neurons may compete against one another for integration into a memory trace. Specifically, neurons in the lateral nucleus of the amygdala with relatively higher levels of cAMP Responsive Element Binding Protein (CREB) seem to be preferentially allocated to a fear memory trace, while neurons with relatively decreased CREB function seem to be excluded from a fear memory trace. CREB is a ubiquitou...

We used a double transgenic tetracycline system to conditionally express A-CREB, a dominant negative protein that prevents the DNA binding and function of cAMP-responsive element binding protein (CREB) family members, in mouse basal epidermis using the keratin 5 promoter. There was no phenotype in the adult. However, following a 7,12-dimethylbenz(a)anthracene (DMBA)/phorbol-12-myristate-13-acet...

Protein kinase A (PKA)/cAMP response element-binding (CREB) protein signaling pathway, contributing to impaired neurogenesis parallel to depressive-like behaviors, has been identified as the crucial factor involved in the antidepressant response of acupuncture. However, the molecular mechanisms associated with antidepressant response of acupuncture, neurogenesis, and depressive-like behaviors a...

Gamma interferon (IFN-gamma) is a crucial cytokine for protection against Mycobacterium tuberculosis, but the mechanism of IFN-gamma transcription is still unclear. The cyclic AMP (cAMP) responsive element binding (CREB) proteins belong to the bZip (basic leucine zipper) family of transcription factors and are essential for T-cell function and cytokine production. This study focused on the capa...

Members of the mammalian ATF/CREB family of transcription factors, which are associated with regulation by cyclic AMP and viral oncogenes, bind common DNA sequences (consensus TGACGTCA) via a bZIP domain. In the yeast Saccharomyces cerevisiae, ATF/CREB-like sequences confer either repression or activation of transcription, depending on the promoter context. By isolating mutations that alleviate...

The cAMP and ERK/MAP kinase (MAPK) signal transduction pathways are critical for hippocampus-dependent memory, a process that depends on CREB-mediated transcription. However, the extent of crosstalk between these pathways and the downstream CREB kinase activated during memory formation has not been elucidated. Here we report that PKA, MAPK, and MSK1, a CREB kinase, are coactivated in a subset o...

To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner. The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place prefe...

cAMP Responsive Element Binding Protein (CREB) is a member of a family (CREB/ATF) of structurally related transcription factors that bind to promoter CRE sites. In mammals, at least three genes encode the CREB-like proteins, CREB, CREM (cAMP Response Element Modulator) and ATF-1 (Activating Transcription Factor) (Hoeffler et al., 1988; Rehfuss et al., 1991; Foulkes et al., 1992). These three ge...

Amaç: Diabetes mellitus (DM), mortalite ve morbidite oranı yüksek olan metabolik bir hastalıktır. DM’nin nörodavranışsal değişikliklere lökomotor aktivitede bozulmaya neden olduğu gösterilmiştir. Siklik AMP Regülatuar Eleman Bağlayıcı Protein (CREB) Beyin kaynaklı nörotrofik faktör (BDNF) proteinleri, beyindeki hafıza, öğrenme ruh hâli değişiklikleri gibi sayısız işlevde düzenleyici rol oynar. ...

The overactive hypothalamic–pituitary–adrenal (HPA) axis is believed to trigger the overproduction of corticosterone, leading neurotoxicity in brain. Fisetin a flavonoid commonly found fruits and vegetables. It has been suggested possess various biological activities, including antioxidant, anti-inflammatory, neuroprotective effects. This study aims explore potential properties fisetin against ...