Running title: PAK control of chemotaxis 2 SUMMARY We have identified a new Dictyostelium p21-activated protein kinase, PAKc, that we demonstrate to be required for proper chemotaxis. PAKc contains a Rac-GTPase binding (CRIB) and autoinhibitory domain, a PAK-related kinase domain, an N-terminal phosphatidylinositol binding domain, and a C-terminal extension related to the Gβγ binding domain of ...

Objective: Bed-sharing is associated with sudden infant death syndrome and accidental suffocation and strangulation in bed. The purpose of this study was to identify risk factors for newborn bed-sharing. Methods: Postpartum mothers from a university maternity service were contacted by phone to complete a survey. Demographic and environmental data were collected; newborn bed-sharing and sleep en...

INFANT MONITORING SYSTEM P. Sushma Chowdary1 and S. Aruna2 1Department of Electronics and Communication Engineering, Andhra University College of Engineering (A), Andhra University, Visakhapatnam, AP 530 003, India. E-mail: [email protected] 2Department of Electronics and Communication Engineering, Andhra University College of Engineering (A), Andhra University, Visakhapatnam, AP 530 00...

Proteins exist in a delicate balance between the native and unfolded states, where thermodynamic stability may be sacrificed to attain the flexibility required for efficient catalysis, binding, or allosteric control. Partition-defective 6 (Par-6) regulates the Par polarity complex by transmitting a GTPase signal through the Cdc42/Rac interaction binding PSD-95/Dlg/ZO-1 (CRIB-PDZ) module that al...

BACKGROUND AND OBJECTIVES The American Academy of Pediatrics stresses that NICUs should endorse and model the sudden infant deaths syndrome risk-reduction recommendations significantly before anticipated discharge of the infant. Medical personnel are critical role models for parents, and the way they position infants in the hospital strongly influences parental practices at home. The aims of th...

Software makers continue to divide the computing world into smaller entities, from huge platforms to little components, in order to keep up with the changing pace of technology. As a result, it becomes harder to unify disparate running environments into one standard or framework. And it is even more difficult to ensure integration testing of all or even parts of the user demands for different l...

The α resonant scattering on 18 Ne was measured in inverse kinematics to understand the -clustering of proton-rich 22 Mg nucleus, performed at CNS Radio-Isotope Beam Separator (CRIB) Center for Nuclear Study, University Tokyo, located RIBF RIKEN Nishina Center. excitation function obtained energies 10–16 MeV by adopting thick-target method. Several resonances were evident present work, which im...

communication between subarachnoid and per lymphatic spaces can be due to a deficiency of lamina crib rosa (stapes gusher). recognition of the condition may alter the course of treatment that can avoid perilymph gushing. a five-year-old boy presented with a history of congenital hearing loss and recurrent meningitis. the computed tomography (ct) of the temporal bone showed severe bilateral dysp...