Tooth bleaching procedures have become very popular since their first introduction in dental clinical practice. There are concerns about the effects of exposure of oral tissues to bleaching agents. The purpose of the present study was to determine the cytotoxic effect of 2 bleaching agents (sodium perborate and carbamide peroxide) against 2 fibroblastic cell lines. BHK21/ C13 baby hamster kidne...

objective: crocin, the carotenoid isolated from saffron, has numerous medicinal properties which include anticancer and antioxidant activities. some antioxidants, such as carotenoids, can act as pro-oxidants at higher dosages and therefore induce tissue damage. in this situation antioxidant defense systems in the liver activate to prevent tissue damage. this study investigates the possible toxi...

The development of a convenient mathematical application for testing the antioxidant and prooxidant potential of standard and novel therapeutic agents is essential for the research community and food industry in order to perform more precise evaluations of products and processes. In this work, a simple non-linear dose-time tool to test the effectiveness of compounds for competitive assays is pr...

Crocetin glycoside, crocin is a pharmacologically active component of Crocus sativus L. (saffron) that has been used in traditional Chinese medicine. Previously we demonstrated that crocin inhibited apoptosis in PC-I2 cells by affecting the function of tumor necrosis factor-α. In this study, we found that depriving cultured PC-12 cells of serum/glucose causes a rapid increase in cellular cerami...

THE EFFECT OF CROCIN ON LIVER DYSFUNCTION INDUCED BY LIPOPOLYSACCHARIDE/D-GALACTOSAMINE IN MALE MOUSE

Crocin( Crocetin di-gentiobiose ester ) is the chemical constituent isolated from the Saffron, the dried trifid stigma of the plant Crocus sativus L. and also from the fruits of Gardenia(Gardenia jasminoides Ellis) It is found to be effective as antiproliferative, anti-oxidant, learning and memory enhancer, brain neurodegenerative disorder, sperm cryoconservation, biosurfactant, alzheimer disor...

background: obesity is pandemic worldwide and a strong risk factor for cardio-metabolic disorders. the few approved anti-obesity drugs have poor efficacy and safety profile. thus, there is an urgent need for new anti-obesity agents. according to the traditional medicine and a clinical trial, saffron may have anorexigenic and anti-obesity effects which need further investigation. objectives: eva...

objectives: crocin, a constituent of saffron and yellow gardenia, possesses anti-nociceptive effects. in the present study, we investigated the effects of intra-fourth ventricle injection of crocin in a rat model of orofacial pain. the contribution of opioid system was assessed using intra-fourth ventricle injection of naloxone, an opioid receptor antagonist. materials and methods: a guide cann...

Objectives: This study aimed to evaluate the effect of crocin and treadmill exercise on oxidative stress, sperm parameters, testis structure in streptozotocin (STZ)-induced diabetic rats. Materials Methods: In this experimental study, 64 rats induced by a single intraperitoneal (IP) injection STZ (50 mg/ kg) were assigned following groups (n=8/each): healthy control group, group treated daily w...