The inhalation of sodium cromoglycate (SCG) is an effective and widely used treatment for asthma. Rarely, reactions to this drug, such as pulmonary eosinophilia, allergic granulomatosis, anaphylaxis, angioneurotic oedema, urticaria, and skin eruptions, have been reported.' Although mild wheeze may develop in some patients after inhaling SCG, in only one patient has the provocation of severe bro...

Each stereoisomer of 3-[methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, 1a-d, was prepared and evaluated in vitro for its ability to prevent mediator release induced by different degranulating agents from rodent mast cells and also in vivo against passive cutaneous anaphylaxis. The manner in which the stereoisomers prevented direct membrane activation was found to be highly dependen...