The classical acute-phase protein, C-reactive protein (CRP), is an exquisitely sensitive systemic marker of disease with broad clinical utility for monitoring and differential diagnosis. Inflammation, the key regulator of CRP synthesis, plays a pivotal role in atherothrombotic cardiovascular disease. There is a powerful predictive association between raised serum CRP values and the outcome of a...

c-reactive protein (crp) response was studied in 44 patients with acute angina pectoris admitted to the coronary care unit. 71 % of patients with acute myocardial infarction (mi)had positive crp test while 73% of patients presumed to have unstable angina pectoris had negative crp test. this test can be helpful in differentiating between acute mi and unstable angina pectoris.

BACKGROUND Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP. METHODS AND RESULTS We studied serum CRP in 3301 Framingham Heart Study (FHS) participants (mean age 61 years, 53% women). Twelve clinical covariates explained 26% of the variab...

The envelopes of elementary bodies of Chlamydia spp. consist largely of disulfide-cross-linked major outer membrane protein (MOMP) and two cysteine-rich proteins (CRPs). The MOMP gene of Chlamydia psittaci 6BC has been sequenced previously, and the genes encoding the small and large CRPs from this strain were cloned and sequenced in this study. The CRP genes were found to be tandemly arranged o...

C-reactive protein (CRP) has several properties that suggest that it may function as a bacterial opsonin. CRP shows binding reactivity with pneumococcal C-polysaccharide, the cell wall carbohydrate of Streptococcus pneumoniae. In this study we have demonstrated protection of mice against serotypes 3 and 4 of S. pneumoniae infection by a single prior injection of CRP. This effect was seen both i...

Abstract Background Research and clinical studies have established a pivotal role of inflammation in the development progression both cardiac vascular diseases, responsive to injurious factors such as smoking, hypertension, dyslipidemia, hyperglycemia. This study analyzed association various lipids, HbA1c glucose with high-sensitivity CRP (hs-CRP), marker low-grade chronic inflammation, communi...

Infective metacyclic promastigote forms of Leishmania mexicana are introduced by the bite of sandfly vectors into their human hosts where they transform into the amastigote form. The kinetics of this process was examined in vitro in response to different combinations of temperature (26 degrees C or 32 degrees C), pH (7.2 or 5.5), and exposure to human serum. Little transformation occurred at 26...

STUDY QUESTION What is the heritability of C-reactive protein (CRP) levels in women with polycystic ovary syndrome (PCOS) and their first-degree relatives? SUMMARY ANSWER Women with PCOS and their siblings are more likely to have elevated CRP levels when both of their parents have elevated CRP. This PCOS family-based study indicates that CRP levels are likely a heritable trait. WHAT IS KNOW...

Biosynthetic labeling with [35S]met and immunoprecipitation with anti-C-reactive protein (CRP) antibodies and Staphylococcus aureus indicate that cell surface CRP is produced by lymphocytes. The ability of anti-CRP to reduce NK activity, and the demonstration that 125I-anti-CRP-labeled PBL are found in low-density Percoll fractions associated with large granular lymphocyte (LGL) and NK activity...

Aims Recent studies have shown that C-reactive protein is not just an indicator of cardiovascular disease (CVD) incidence and mortality. Thus, early detection of a continous increase in CRP concentrations may be useful in predicting subsequent development of CVD or metabolic syndrome. The objective of this study was to analyze high sensitivity C-reactive protein (hs-CRP) in apparently healthy y...